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上海药物研究所 [21]
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期刊论文 [29]
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Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
Lipoprotein-associated phospholipase A2: The story continues
期刊论文
MEDICINAL RESEARCH REVIEWS, 2020, 卷号: 40, 期号: 1, 页码: 79-134
作者:
Huang, Fubao
;
Wang, Kai
;
Shen, Jianhua
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  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
fragment-based lead discovery
inflammation
inhibitors
lipoprotein-associated phospholipase A2
vascular diseases
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
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  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Identification of Imidazo[1,2-b]pyridazine derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors
期刊论文
ACS Medicinal Chemistry Letters, 2019
作者:
Chunjian Liu
;
James Lin
;
Ryan Moslin
;
John S Tokarski
;
Jodi K. Muckelbauer
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/13
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: Vol.162, 页码: 543-554
作者:
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
Antitumor activity
STAT3 inhibitors
Napabucasin derivatives
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 .
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.162, 页码: 543-554
作者:
Li, Chungen
;
Chen, Caili
;
An, Qi
;
Yang, Tao
;
Sang, Zitai
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/17
DRUG
derivatives
*CELLULAR
signal
transduction
*GENETIC
transcription
*QUINOLINE
derivatives
*STRUCTURE-activity
relationship
in
pharmacology
Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 4, 页码: 1207-1219
作者:
Xie, Chengying
;
Wan, Xiaozhe
;
Quan, Haitian
;
Zheng, Mingyue
;
Fu, Li
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  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
angiogenesis
anlotinib
tyrosine kinase inhibitor
VEGF
VEGFR2
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 2
作者:
Colin-Lozano, Blanca
;
Estrada-Soto, Samuel
;
Chavez-Silva, Fabiola
;
Gutierrez-Hernandez, Abraham
;
Ceron-Romero, Litzia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
diabetes
GPR40
AKRB1
PPAR gamma
GLUT-4
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 .
期刊论文
European journal of medicinal chemistry, 2018, 卷号: Vol.162, 页码: 543-554
作者:
Li Chungen
;
Chen Caili
;
An Qi
;
Yang Tao
;
Sang Zitai
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/02/25
Antitumor
activity
Napabucasin
derivatives
STAT3
inhibitors
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