CORC

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CORC

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GP205, a new hepatitis C virus NS3/4A protease inhibitor, displays higher metabolic stability in vitro and drug exposure in vivo 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11
作者:  Zhai, Pei-bin;  Qing, Jie;  Li, Ben;  Zhang, Lin-qi;  Ma, Lan
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/05
The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity 期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 30, 页码: 4493-4554
作者:  Wang, Shuni;  Wang, Yibing;  Wang, Jiang;  Sato, Tatsunori;  Izawa, Kunisuke
收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08
Tailor-Made alpha-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA) 期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 期号: 16, 页码: 2757-2774
作者:  Sato, Tatsunori;  Izawa, Kunisuke;  Luis Acena, Jose;  Liu, Hong;  Soloshonok, Vadim A.
收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08
Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base 期刊论文
AMINO ACIDS, 2016, 卷号: 48, 期号: 4, 页码: 973-986
作者:  Kawashima, Aki;  Shu, Shuangjie;  Takeda, Ryosuke;  Kawamura, Akie;  Sato, Tatsunori
收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08
树鼩抗病毒先天免疫RLR通路基因的功能鉴定 学位论文
博士, 北京: 中国科学院研究生院, 2014
作者:  许凌
收藏  |  浏览/下载：48/0  |  提交时间：2016/06/29
Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 8, 页码: 1074-1081
作者:  Yu, Ye;  Jing, Jing-feng;  Tong, Xian-kun;  He, Pei-lan;  Li, Yuan-chao
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08
Computational Study on the Drug Resistance Mechanism against HCV NS3/4A Protease Inhibitors Vaniprevir and MK-5172 by the Combination Use of Molecular Dynamics Simulation, Residue Interaction Network, and Substrate Envelope Analysis 期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2014, 卷号: 54, 期号: 2
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收藏  |  浏览/下载：3/0  |  提交时间：2014/12/05
discoveringnovelantihcvcompoundswithinhibitoryactivitiestowardhcvns34aprotease 期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 8, 页码: 1074
作者:  Yu Ye;  Jing Jingfeng;  Tong Xiankun;  He Peilan;  Li Yuanchao
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01
DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication 期刊论文
VIROLOGY, 2013, 卷号: 435, 期号: 2
作者:  Kang, Xi;  Chen, Xi;  He, Ying;  Guo, Deyin;  Guo, Lin
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
HCV  NS3/4A  DDB1  Replication  
Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: A computational study 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 卷号: 1820, 期号: 10, 页码: 1526-1534
作者:  Pan, DB;  Xue, WW;  Zhang, WQ;  Liu, HX;  Yao, XJ
收藏  |  浏览/下载：3/0  |  提交时间：2015/12/29

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