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上海药物研究所 [15]
武汉大学 [3]
北京大学 [2]
清华大学 [1]
西安交通大学 [1]
大连理工大学 [1]
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期刊论文 [22]
会议论文 [1]
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Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 1, 页码: 27-33
作者:
Wang, Lei
;
Qiao, Guan-Hua
;
Hu, Hai-Ning
;
Gao, Zhao-Bing
;
Nan, Fa-Jun
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
KCNQ channel
retigabine
subtype selectivity
agonist
A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Bai, Fang
;
Pi, Xiaoping
;
Li, Ping
;
Zhou, Pingzheng
;
Yang, Huaiyu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
KCNQ2 potassium channel
hill equation
thermodynamic model
patch clamp electrophysiology
activators
A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel.
期刊论文
Frontiers in pharmacology, 2018, 卷号: 9, 页码: -
作者:
Bai F.
;
Pi X.
;
Li P.
;
Zhou P.
;
Yang H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/02
KCNQ2 potassium channel
hill equation
thermodynamic model
patch clamp electrophysiology
activators
Grayanane diterpenoids with diverse bioactivities from the roots of Pieris formosa
期刊论文
2018, 卷号: 74, 期号: 3, 页码: 375-382
作者:
Niu, Chang-Shan
;
Li, Yong
;
Liu, Yun-Bao
;
Ma, Shuang-Gang
;
Liu, Fei
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Pieris formosa
Grayanane diterpenoids
Analgesic activity
Antifeedant activity
KCNQ2 potassium channel
Gene mutation analysis of 175 Chinese patients with early-onset epileptic encephalopathy
期刊论文
CLINICAL GENETICS, 2017
Zhang, Q.
;
Li, J.
;
Zhao, Y.
;
Bao, X.
;
Wei, L.
;
Wang, J.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2017/12/03
CDKL5
early-onset epileptic encephalopathy
KCNQ2
recommending treatment
targeted next-generation sequencing
KCNQ2 ENCEPHALOPATHY
POTASSIUM CHANNEL
CDKL5
SPECTRUM
LOCALIZATION
EPILEPSIES
QUINIDINE
INFANCY
GAIN
Endoplasmic reticulum retention of KCNQ2 potassium channel mutants following temperature elevation
会议论文
作者:
Yu, Fang
;
Xu, Jian
;
Xiao, Zheman
;
Peng, Biwen
;
He, Xiaohua
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Endoplasmic reticulum retention of KCNQ2 potassium channel mutants following temperature elevation
期刊论文
BIO-MEDICAL MATERIALS AND ENGINEERING, 2017, 卷号: 28
作者:
Yu, Fang
;
Xu, Jian
;
Xiao, Zheman
;
Peng, Biwen
;
He, Xiaohua
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
KCNQ2
ion channels
temperature
febrile seizures
benign familial neonatal convulsions
Endoplasmic reticulum retention of KCNQ2 potassium channel mutants following temperature elevation
期刊论文
BIO-MEDICAL MATERIALS AND ENGINEERING, 2017, 卷号: 28
作者:
Peng, Biwen
;
Yu, Fang
;
Xu, Jian
;
He, Xiaohua
;
Xiao, Zheman
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
KCNQ2
ion channels
temperature
febrile seizures
benign familial neonatal convulsions
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clampbased high-throughput screening techniques
期刊论文
Acta Pharmacologica Sinica, 2016, 卷号: 37, 期号: 1, 页码: 105
作者:
Yue Jinfeng
;
Qiao Guanhua
;
Liu Ni
;
Chen Xueqin
;
Nan Fajun
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
POTASSIUM CHANNEL
KV7 CHANNELS
EPILEPSY
IDENTIFICATION
GENE
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
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