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上海药物研究所 [11]
西北高原生物研究所 [10]
北京大学 [4]
兰州理工大学 [3]
大连化学物理研究所 [3]
厦门大学 [2]
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期刊论文 [42]
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A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic
Trichoderma
sp. Z43
期刊论文
CHEMISTRY & BIODIVERSITY, 2023, 页码: 5
作者:
Shi, Zhen-Zhen
;
Yin, Xiu-Li
;
Song, Yin-Ping
;
Ji, Nai-Yun
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/15
antimicroalgal activity
harziane diterpene
steroid
structure elucidation
Trichoderma
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
期刊论文
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2022, 卷号: 22
作者:
Xu, Yipeng
;
Pachnikova, Gabriela
;
Wang, He
;
Wu, Yaoyao
;
Przybilla, Dorothea
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  |  
浏览/下载:10/0
  |  
提交时间:2022/12/23
IC50
docetaxel
spheroids
drug testing
preclinical models
prostate cancer
2D clinical models
3D clinical models
cell culture
Inhibitory Effect of Acer truncatum Bunge Seed Coat Extract on Fatty Acid Synthase, Differentiation and Lipid Accumulation in 3T3-L1 Adipocytes
期刊论文
MOLECULES, 2022, 卷号: 27, 期号: 4
作者:
Liang, Yan
;
Kong, Fan
;
Ma, Xiaofeng
;
Shu, Qingyan
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/07
fatty acid synthase
Acer truncatum Bunge
inhibitor
obesity
Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel alpha-Glucosidase Inhibitor
期刊论文
MOLECULES, 2021, 卷号: 26, 期号: 15
作者:
Dong, Qi
;
Hu, Na
;
Yue, Huilan
;
Wang, Honglun
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  |  
浏览/下载:15/0
  |  
提交时间:2021/11/18
hypericin
alpha-glucosidase inhibitor
mechanism
Bioassay-guided isolation of antioxidant, antimicrobial, and antiviral constituents of Cordia dichotoma fruits
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 172, 期号: 11, 页码: 1-12
作者:
Yaermaimaiti, S (Yaermaimaiti, Saimijiang) 1 , 2 , 3
;
Wu, T (Wu, Tao) 1 , 2
;
Aisa, HA (Aisa, Haji Akber) 1 , 2 , 3
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  |  
浏览/下载:28/0
  |  
提交时间:2021/12/06
Cordia dichotoma
Bioassay-guided isolation
Phenolics constituents
Structure-activity relationships
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1337-1360
作者:
Yang, Yaxi
;
Zhang, Rukang
;
Li, Zhaojun
;
Mei, Lianghe
;
Wan, Shili
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  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 254, 页码: -
作者:
Liu, Yong-Zhe
;
Zhang, Zhi-Peng
;
Fu, Zhi-Wei
;
Yang, Kun
;
Ding, Ning
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  |  
浏览/下载:13/0
  |  
提交时间:2020/09/10
Per- and polyfluoroalkyl substances (PFASs)
UDP-Glucuronosyltransferases (UGTs)
Half inhibition concentration (IC50)
Inhibition type
Inhibition kinetic parameters (Ki)
In vitro-in vivo extrapolation (IVIVE)
Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 14
作者:
Zhu, Yan
;
Klausen, Christian
;
Zhou, Jieyun
;
Guo, Xiangjie
;
Zhang, Yu
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  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:
Zheng, Yue-ming
;
Wang, Wan-fu
;
Li, Yan-fen
;
Yu, Yong
;
Gao, Zhao-bing
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Nav1.7 channels
analgesics
CNV1014802
inactivated state
paroxysmal extreme pain disorder
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