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Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:  Wu, Ya-li;  Xue, Ya-ru;  Guo, Zi-tao;  Chen, Zhen-dong;  Ge, Xin-yu
收藏  |  浏览/下载:22/0  |  提交时间:2021/08/17
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity 期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:  Qiao, Shida;  Feng, Sisi;  Wu, Zhitao;  He, Ting;  Ma, Chen
收藏  |  浏览/下载:27/0  |  提交时间:2021/05/24
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:  Liu, Xiao-yun;  Guo, Zi-tao;  Chen, Zhen-dong;  Zhang, Yi-fan;  Zhou, Jia-lan
收藏  |  浏览/下载:76/0  |  提交时间:2020/07/01
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor 期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:  Zhang, Leduo;  Mao, Yu;  Gao, Zhiwei;  Chen, Xiaoyan;  Li, Xin
收藏  |  浏览/下载:46/0  |  提交时间:2020/07/01
Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease 期刊论文
PHARMACOLOGICAL RESEARCH, 2019, 卷号: 150, 页码: 14
作者:  Zhang, Yu;  Wu, Qimei;  Zhang, Lei;  Wang, Qing;  Yang, Zexian
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/01
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/01
Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans 期刊论文
DRUG METABOLISM AND DISPOSITION, 2019, 卷号: 47, 期号: 8, 页码: 843-853
作者:  Li, Xiuli;  Sun, Jingchao;  Guo, Zitao;  Zhong, Dafang;  Chen, Xiaoyan
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/01
Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2 期刊论文
Nanoscale, 2019, 卷号: 11, 期号: 11, 页码: 4767-4780
作者:  Mei, Linqiang;  Zhang, Xiao;  Yin, Wenyan;  Dong, Xinghua;  Guo, Zhao
收藏  |  浏览/下载:79/0  |  提交时间:2019/04/22
Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2 期刊论文
Nanoscale, 2019, 卷号: 11, 期号: 11, 页码: 4767-4780
作者:  Mei, Linqiang;  Zhang, Xiao;  Yin, Wenyan;  Dong, Xinghua;  Guo, Zhao
收藏  |  浏览/下载:79/0  |  提交时间:2019/04/22
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia 期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:  Wu Chenglin;  Xi Cong;  Tong Junhua;  Zhao Jing;  Jiang Hualiang
收藏  |  浏览/下载:52/0  |  提交时间:2020/07/01


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