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上海药物研究所 [20]
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期刊论文 [40]
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Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Effect of the cargo lipophilicity on powder micromeritics properties of drug-loaded solid lipid microparticles
期刊论文
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 卷号: 51
作者:
Ma, Cheng
;
Wang, Wenhao
;
Huang, Zhengwei
;
Chen, Xiaona
;
Ye, Weifen
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/12/05
SLMs
Powder micromeritic properties
Lipophilicity
Interparticle force
Novel 2-arylthiopropanoyl-CoA inhibitors of alpha-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 92
作者:
Yevglevskis, Maksims
;
Nathubhai, Amit
;
Wadda, Katty
;
Lee, Guat L.
;
Al-Rawi, Suzanne
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/11
alpha-Methylacyl-CoA racemase (AMACR, P504S)
Branched-chain fatty acid
metabolism
Castrate-resistant prostate cancer (CRPC)
Drug
lipophilicity
Enzyme inhibitors
Ibuprofen
Mixed competitive
inhibition
Rational drug design
Structure-activity relationships
Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents
期刊论文
Bioorganic Chemistry, 2019, 卷号: 92
作者:
Yevglevskis M.
;
Nathubhai A.
;
Wadda K.
;
Lee G.L.
;
Al-Rawi S.
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  |  
浏览/下载:38/0
  |  
提交时间:2019/12/11
Branched-chain fatty acid metabolism
Castrate-resistant prostate cancer (CRPC)
Drug lipophilicity
Enzyme inhibitors
Ibuprofen
Mixed competitive inhibition
Rational drug design
Structure-activity relationships
α-Methylacyl-CoA racemase (AMACR, P504S)
A Drug with Lipophilicity-Dependent Potency Can Be Metabolically Stable: Discovery of a Potent and Selective Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist as an Orally Bioavailable Anti-Inflammatory Agent
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 23, 页码: 10412-10414
作者:
Wang, Yibing
;
Liu, Hong
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  |  
浏览/下载:78/0
  |  
提交时间:2019/01/08
Design, synthesis and structure activity relationship studies of GPR40 agonists containing amide linker
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 175-194
作者:
Chen, Tingting
;
Ning, Mengmeng
;
Ye, Yangliang
;
Wang, Kai
;
Leng, Ying
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
GPR40
FFAR1
Insulin secretion
Type 2 diabetes mellitus
CNS
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2697-2717
作者:
Li, He
;
Huang, Qi
;
Chen, Cheng
;
Xu, Bin
;
Wang, He-Yao
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Catalytic asymmetric trifluoromethylthiolation via enantioselective [2,3]-sigmatropic rearrangement of sulfonium ylides
期刊论文
NATURE CHEMISTRY, 2017
Zhang, Zhikun
;
Sheng, Zhe
;
Yu, Weizhi
;
Wu, Guojiao
;
Zhang, Rui
;
Chu, Wen-Dao
;
Zhang, Yan
;
Wang, Jianbo
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
2,3 SIGMATROPIC REARRANGEMENT
ALLYL ARYL SULFIDES
C-H ACTIVATION
DONOR/ACCEPTOR CARBENOIDS
BOND FORMATION
METAL CARBENE
TANDEM YLIDE
SULFUR
GENERATION
COMPLEXES
Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 8, 页码: 683-692
作者:
Wang, Bao-Cheng
;
Wang, Li-Jun
;
Jiang, Bo
;
Wang, Shuai-Yu
;
Wu, Ning
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2017/09/30
Application Of Fluorine
Anticancer
Antimicrobial
Anti-inflammatory
Antivirus Activity
Drug Design
Importance Of Fluorinated Compounds
Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2017, 卷号: 24, 期号: 35, 页码: 3921-3937
作者:
Cao, Hua
;
Wang, Kai
;
Ye, Yang-Liang
;
Shen, Jian-Hua
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Intestine targeted drugs
design strategies
lipophilicity
aqueous solubility
molecular weight
soft drugs
prodrugs
efflux transporters
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