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科研机构
上海药物研究所 [65]
北京大学 [20]
大连化学物理研究所 [10]
湖南大学 [5]
昆明植物研究所 [4]
清华大学 [3]
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期刊论文 [134]
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Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress
期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 卷号: 9, 页码: 13
作者:
Guo, Yuanhao
;
Shen, Di
;
Zhou, Yanfeng
;
Yang, Yutong
;
Liang, Jinzhao
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/03/17
ER stress
morphological classification
image biomarker
deep learning
homeostasis
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
期刊论文
MOLECULAR CELL, 2021, 卷号: 81, 期号: 19, 页码: 4076-+
作者:
Liu, Zhiwei
;
Liu, Yingluo
;
Qian, Lili
;
Jiang, Shangwen
;
Gai, Xiameng
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  |  
浏览/下载:27/0
  |  
提交时间:2021/12/01
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
The ups, downs and new trends of IDO1 inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 12
作者:
Chen, Shulun
;
Tan, Jing
;
Zhang, Ao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/08/17
Immunotherapy
Cancer
Indoleamine 2,3-dioxygenase
Tryptophan 2,3-dioxygenase
Inhibitors
Checkpoint Inhibitor
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13
作者:
Wang, Yu-xiang
;
Zhang, Xu
;
Ma, Qing-yang
;
Hu, Lan-dian
;
Zhang, Xi
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
PI3K alpha inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8(+)T cells and promoting fatty acid metabolism
期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9, 期号: 8, 页码: 16
作者:
Sun, Pu
;
Zhang, Xi
;
Wang, Rong-Jing
;
Ma, Qing-Yang
;
Xu, Lan
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/11/04
tumor microenvironment
immunomodulation
immunologic memory
lymphocytes
tumor-infiltrating
macrophages
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