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上海药物研究所 [48]
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A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine
期刊论文
NUCLEIC ACIDS RESEARCH, 2022
作者:
Zhou, Fang
;
Wang, Peng
;
Chen, Jianghuai
;
Zhu, Zhijia
;
Li, Youshan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/12/23
Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry
期刊论文
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2022, 卷号: 36
作者:
Zhang, Hongjian
;
Hu, Zhen
;
Zhang, Huiping
;
Sun, Xiyan
;
Yang, Jianming
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  |  
浏览/下载:42/0
  |  
提交时间:2022/03/28
Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Light-induced efficient and residue-selective bioconjugation of native proteins via indazolone formation
期刊论文
RSC ADVANCES, 2021, 卷号: 11, 期号: 4, 页码: 2235-2241
作者:
Guo, An-Di
;
Wu, Ke-Huan
;
Chen, Xiao-Hua
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2021/05/24
Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy
期刊论文
ADVANCED HEALTHCARE MATERIALS, 2021
作者:
Zhao, Di
;
Jiang, Kai
;
Wang, Yuqi
;
Cheng, Jin
;
Mo, Fangli
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  |  
浏览/下载:122/0
  |  
提交时间:2021/03/15
controllable esterase response
high loading efficiency
lung targeting
multi-drug resistance
universal drug encapsulation
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 6, 页码: 491-499
作者:
Chen, Wei-Ying
;
Liang, Guang-Yan
;
Zheng, Zuo-Liang
;
Wu, Yun-Shan
;
Xu, Fang-Fang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Protosappanin B
Metabolic pathways
UPLC-TOF-MS
MS
Plasma
Bile
Feces
Urine
Intestinal bacteria sample
Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation
期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 13
作者:
Guo, An-Di
;
Wei, Dan
;
Nie, Hui-Jun
;
Hu, Hao
;
Peng, Chengyuan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/12/24
Microalgae-derived cellulose/inorganic nanocomposite rattle-type microspheres as an advanced sensor for pollutant detection
期刊论文
CHEMICAL ENGINEERING JOURNAL, 2020, 卷号: 395, 页码: 1-9
作者:
Bi, Lei
;
Chen, Yi-Ping
;
Wang, Chen
;
Su, Jing
;
Pan, Gang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/09/14
Hollow materials
Porous materials
Microspheres
Core-shell structure
Green synthesis
Immunoassay
Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 页码: 6
作者:
Shi, Wei
;
Tang, Feng
;
Ao, Jiwei
;
Yu, Qun
;
Liu, Junjie
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/21
acylation
click chemistry
peptides
rearrangements
silver
Conjugation of beta-Glucan with the Hydrazone and Disulfide Linkers Markedly Improves the Immunogenicity of Zika Virus E Protein
期刊论文
MOLECULAR PHARMACEUTICS, 2020, 卷号: 17, 期号: 6, 页码: 1933-1944
作者:
Qi, Jinming
;
Yin, Ying
;
Yu, Weili
;
Shen, Lijuan
;
Xu, Junjie
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/23
Zika virus
beta-glucan
E protein
adjuvant
hydrazine
disulfide
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