×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [11]
厦门大学 [1]
华中师范大学 [1]
武汉大学 [1]
内容类型
期刊论文 [13]
学位论文 [1]
发表日期
2020 [4]
2018 [4]
2017 [2]
2016 [2]
2015 [1]
2014 [1]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共14条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Design, Synthesis, and Biological Activities of Novel Triazolothiadiazole Derivatives Linked with Amino Side Chain Containing Urea Group as DOT1L Inhibitors
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 8, 页码: 2450-2459
作者:
Liu Na
;
Guo Siqi
;
Liu Junfang
;
Chen Yantao
;
Xu Xiaoming
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
triazolothiadiazole
triazolothiadiazine
nucleophilic substitution
Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 5, 页码: 1345-1354
作者:
Xu Xiaoming
;
Guo Siqi
;
Zhang Jing
;
Chen Yantao
;
Kang Yaqing
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
ttriazolo-thiadiazole
structural modification
hydrophobic substituent
structure-activity analysis
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
;
Niu, Ao
;
Li, Yuanqing
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
连氨基脲链的三氮唑并噻二唑类DOT1L抑制剂的设计、合成及活性
期刊论文
有机化学, 2020, 卷号: 40, 期号: 8, 页码: 2450
作者:
刘娜
;
郭思岐
;
刘俊芳
;
陈彦韬
;
徐晓明
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
triazolothiadiazole
triazolothiadiazine
nucleophilic substitution
DOT1L抑制剂
三氮唑并噻二唑
三氮唑并噻二嗪
亲核取代
Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654
作者:
Zhang, Li
;
Chen, Yantao
;
Liu, Na
;
Li, Linjuan
;
Xiao, Senhao
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Pyrimidylaminoquinoline
Nonnucleoside DOT1L inhibitors
Amino side chains
Mixed-linage leukemia
Histone lysine methyltransferase
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758
作者:
Song, Yakai
;
Li, Linjuan
;
Chen, Yantao
;
Liu, Jingqiu
;
Xiao, Senhao
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
DOT1L
MLL-rearranged leukemia
AlphaLISA
HTS
Novel inhibitors
Convenient preparation of pinometostat and related 5 '-deoxy-5 '-amino adenosine derivatives as well as their activity against DOT1L
期刊论文
TETRAHEDRON LETTERS, 2018, 卷号: 59, 期号: 4, 页码: 415-417
作者:
Liu, Tongchao
;
Ren, Huanming
;
Li, Cong
;
Chen, Guohua
;
Cheng, Maosheng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
DOTI L inhibitor
Pinometostat
Amination
5 '-Deoxy-5 '-amino adenosine derivative
Structure activity relationship
Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival
期刊论文
THERANOSTICS, 2018, 卷号: 8, 期号: 16
作者:
Zhang, Wu
;
Zhao, Chen
;
Zhao, Junmei
;
Zhu, Yongmei
;
Weng, Xiangqin
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
NPM1 mutation
H3K79 hypermethylation
PBX3
HOXA9
DOT1L inhibitor
Preparation of 5 '-deoxy-5 '-amino-5 '-C-methyl adenosine derivatives and their activity against DOT1L
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 22, 页码: 4960-4963
作者:
Liu, Tongchao
;
Xie, Wuchen
;
Li, Cong
;
Ren, Huanming
;
Mao, Yudong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
5'-Deoxy-5'-amino-5'-C-methyl adenosine derivative
N-glycosylation
Nucleoside synthesis
DOT1L inhibitor
Structure activity relationship
BET蛋白抑制剂I-BET151抗肝癌作用的表观遗传学机制研究
学位论文
2017, 2015
周仲实
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2017/06/20
肝细胞癌
I-BET151
Yap1
DOT1L
H3K79me2
HCC
I-BET151
Yap1
DOT1L
H3K79me2
©版权所有 ©2017 CSpace - Powered by
CSpace