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The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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浏览/下载:45/0
  |  
提交时间:2020/07/01
Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish
期刊论文
BIOMATERIALS, 2019, 卷号: 206, 页码: 61-72
作者:
Deng, Shun
;
Fu, Ailing
;
Junaid, Muhammad
;
Wang, Yan
;
Yin, Qian
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  |  
浏览/下载:65/0
  |  
提交时间:2019/06/11
Danio rerio
N-GQDs
Redox system
Antioxidant enzyme activity
USGO
Proton mediated spin state transition of cobalt heme analogs
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 2303
作者:
Zhao, Jianping
;
Peng, Qian
;
Wang, Zijian
;
Xu, Wei
;
Xiao, Hongyan
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  |  
浏览/下载:70/0
  |  
提交时间:2019/12/02
cobalt
cytochrome P450
heme
histidine
imidazole
imidazole derivative
iron
ligand
proton, analogs and derivatives
biocatalysis
chemistry
electron spin resonance
metabolism
oxidation reduction reaction
pH
X ray crystallography, Biocatalysis
Cobalt
Crystallography, X-Ray
Cytochrome P-450 Enzyme System
Electron Spin Resonance Spectroscopy
Heme
Histidine
Hydrogen-Ion Concentration
Imidazoles
Iron
Ligands
Oxidation-Reduction
Protons
Catalytic Function and Application of Cytochrome P450 Enzymes in Biosynthesis and Organic Synthesis
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 9, 页码: 2307-2323
作者:
Jiang Yuanyuan
;
Li Shengying
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  |  
浏览/下载:114/0
  |  
提交时间:2018/12/21
cytochrome P450 enzyme
biosynthesis
organic synthesis
protein engineering
substrate engineering
metabolic engineering
synthetic biology
redox partner
Inherent steroid 17,20-lyase activity in defunct cytochrome P450 17A enzymes
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 2, 页码: 541-556
作者:
Gonzalez, Eric
;
Johnson, Kevin M.
;
Pallan, Pradeep S.
;
Phan, Thanh T. N.
;
Zhang, Wei
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  |  
浏览/下载:16/0
  |  
提交时间:2018/09/06
Biomimetic Models
Effects of pentachlorophenol on the quail (Coturnix japonica) liver detoxification pathway
期刊论文
CHEMOSPHERE, 2017, 卷号: 177, 期号: 0, 页码: 44-50
作者:
Dai, Jiayin
;
Wei, Dongbing
;
Jiang, Peng
;
Wang, Jianshe
;
Sheng, Nan
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浏览/下载:25/0
  |  
提交时间:2018/07/26
Pentachlorophenol
Cytochrome P450
Nf-kappa b
Nrf2
Coturnix Japonica
Electrostatic Spray Ionization from 384-Well Microtiter Plates for Mass Spectrometry Analysis-Based Enzyme Assay and Drug Metabolism Screening
期刊论文
ANALYTICAL CHEMISTRY, 2017
Qiao, Liang
;
Zhong, Xiaoqin
;
Belghith, Emna
;
Deng, Yan
;
Lin, Tzu-En
;
Tobolkina, Elena
;
Liu, Baohong
;
Girault, Hubert H.
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  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
TYROSINASE INHIBITORS
THROUGHPUT
LIBRARIES
MS
VALIDATION
MECHANISM
INFUSION
2D6
Absolute Quantification of Cytochrome P450 and Uridinediphosphate Glucuronosyl Transferase Isoforms by Proteomics-based Approach
期刊论文
chinese journal of analytical chemistry, 2014, 卷号: 42, 期号: 1, 页码: 10-15
作者:
Liu Xi-Dong
;
Zhu Jun
;
Cong Yu-Ting
;
Hu Liang-Hai
;
Ye Ming-Liang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2015/11/17
Uridinediphosphate glucuronosyl transferase
Multiple reaction monitoring
Liver microsome
Cytochrome P450
Liquid chromatography-tandem mass spectrometry
Efficicent (R)-Phenylethanol Production with Enantioselectivity-Alerted (S)-Carbonyl Reductase II and NADPH Regeneration
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 12
作者:
Zhang, Rongzhen
;
Zhang, Botao
;
Xu, Yan
;
Li, Yaohui
;
Li, Ming
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2016/06/23
Role of Multiple MicroRNAs in the Sexually Dimorphic Expression of Cyp2b9 in Mouse Liver
期刊论文
DRUG METABOLISM AND DISPOSITION, 2013, 卷号: 41, 期号: 10, 页码: 1732-1737
作者:
Xie, Xiaofeng
;
Miao, Lingling
;
Yao, Jun
;
Feng, Chenchen
;
Li, Chenggang
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  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
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