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WNT/beta-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma 期刊论文
JOURNAL OF THORACIC DISEASE, 2020, 卷号: 12
作者:  Zhu, Liang;  Yang, Shifeng;  Zheng, Linfeng;  Zhang, Gu;  Cheng, Guoping
收藏  |  浏览/下载：19/0  |  提交时间：2020/12/28
Bioinspired surface hierarchical microstructures of Ti6Al4V alloy with a positive effect on osteoconduction 期刊论文
Surface and Coatings Technology, 2020, 卷号: 388
作者:  Li, Chen;  Yang, Lijun;  Liu, Nan;  Yang, Yong;  Zhao, Jing
收藏  |  浏览/下载：24/0  |  提交时间：2020/03/23
In Vitro Bioactivity and Biocompatibility of Bio-Inspired Ti-6Al-4V Alloy Surfaces Modified by Combined Laser Micro/Nano Structuring 期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 7
作者:  Li, Chen;  Yang, Yong;  Yang, Lijun;  Shi, Zhen;  Yang, Pengfei
收藏  |  浏览/下载：17/0  |  提交时间：2020/06/05
禾本科作物小麦能吸收和积累聚苯乙烯塑料微球 期刊论文
科学通报, 2020, 卷号: 65, 期号: 20, 页码: 2120-2127
作者:  李瑞杰;  李连祯;  张云超;  杨杰;  涂晨
收藏  |  浏览/下载：16/0  |  提交时间：2021/12/01
Metagenomic Sequencing Identifies Highly Diverse Assemblages of Dinoflagellate Cysts in Sediments from Ships' Ballast Tanks 期刊论文
MICROORGANISMS, 2019, 卷号: 7, 期号: 8, 页码: 28
作者:  Shang, Lixia;  Hu, Zhangxi;  Deng, Yunyan;  Liu, Yuyang;  Zhai, Xinyu
收藏  |  浏览/下载：79/0  |  提交时间：2020/01/03
Establishment and application of a dynamic tumor-vessel microsystem for studying different stages of tumor metastasis and evaluating anti-tumor drugs 期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 30, 页码: 17137-17147
作者:  Jing, Bolin;  Luo, Yong;  Lin, Bingcheng;  Li, Jianjun;  Wang, Zhuo A.
收藏  |  浏览/下载：55/0  |  提交时间：2019/09/03
Establishment and application of a dynamic tumor-vessel microsystem for studying different stages of tumor metastasis and evaluating anti-tumor drugs 期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 30, 页码: 17137-17147
作者:  Jing, Bolin;  Luo, Yong;  Lin, Bingcheng;  Li, Jianjun;  Wang, Zhuo A.
收藏  |  浏览/下载：93/0  |  提交时间：2019/12/02
Preparation of ropivacaine loaded PLGA microspheres as controlled-release system with narrow size distribution and high loading efficiency 期刊论文
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 卷号: 562, 页码: 237-246
作者:  Li, Xun;  Wei, Yi;  Lv, Piping;  Wu, Youbin;  Ogino, Kenji
收藏  |  浏览/下载：103/0  |  提交时间：2019/04/03
The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro 期刊论文
POLYMERS, 2019, 卷号: 11, 期号: 2, 页码: 16
作者:  Xu, Jie;  Hu, Xueyan;  Jiang, Siyu;  Wang, Yiwei;  Parungao, Roxanne
收藏  |  浏览/下载：68/0  |  提交时间：2019/06/14
食用蔬菜能吸收和积累微塑料 期刊论文
科学通报, 2019, 卷号: 64, 期号: 9, 页码: 928-934
作者:  李连祯;  周倩;  尹娜;  涂晨;  骆永明
收藏  |  浏览/下载：63/0  |  提交时间：2020/06/17
微塑料  生菜  聚苯乙烯微球  吸收  积累  健康风险  microplastics  lettuce  polystyrene microbeads  uptake  accumulation  human health risk  Microplastic (MP, 100 nm-5 mm) may present an attributable risk to ecosystem and human health, and its pollution has become a global environmental concern. Despite a wealth of information on the accumulation of MPs in aquatic species, there is no information on the uptake and accumulation of MPs by higher plants. Terrestrial edible plants are directly exposed to MPs when agricultural soil was applied with organic manure, sewage sludge as fertilizer or plastic mulching. In this paper, the uptake of two sizes of polystyrene (PS) microbeads (0.2 and 1.0 mum) and then their distribution and migration in an edible plant lettuce were firstly investigated based on laboratory experiments. We used fluorescent markers to track PS microbeads in plant tissues and found fluorescence to be a sensitive and reliable detection method. Sections from untreated control lettuce showed no autofluorescence. When roots were treated with fluorescently labeled PS microbeads, the microbeads could be identified by its fluorescence. Our main study investigated the uptake of 0.2 mum beads, as few luminescence signals were observed in lettuce roots for 1.0 mum beads in our experiment. We observed that 0.2 mum fluorescent microbeads were extracellularly trapped in the root cap mucilage (which is a highly hydrated polysaccharide) and a dark green tip (which was typical of lettuce roots exposed to label PS beads) was usually visible to the naked eye. Confocal images revealed that the PS luminescence signals were mainly located in the vascular system and on the cell walls of the cortex tissue of the roots, indicated that the beads passed through the intercellular space via the apoplastic transport system. Once inside the central cylinder, the 0.2 mum PS beads were transferred from the roots to the stems and leaves via the vascular system following the transpiration stream. We also observed that the PS beads adhered to one another and self-assembled systematically into grape-like and (chain) string-like clusters in the intercellular space of the root and stem vascular tissue of lettuce plant. In contrast to the root and stem, PS beads were dispersed in the leaf tissue. Here, for the first time we provide evidence of the adherence, uptake, accumulation, and translocation of submicrometer MPs within an edible plant. Our findings highlight the previously underappreciated human exposure pathway to MPs through the consumption of contaminated crops and emphasize the need for new management strategies to control the release of MPs waste products into the terrestrial environment. Ultimately, the potential impacts of low range sized MPs on food safety of crop plants and human health need to be urgently considered.  

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