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上海药物研究所 [30]
山东大学 [12]
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Stabilizing photo-sensitive colchicine through rebalancing electron distribution of the reactive tropolone ring
期刊论文
CRYSTENGCOMM, 2021, 卷号: 23, 期号: 1, 页码: 30-34
作者:
Ma, Xiaoyu
;
Zhu, Bingqing
;
Yang, Zeen
;
Jiang, Yuhang
;
Mei, Xuefeng
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2021/05/24
Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 90, 页码: 19
作者:
Bolarin, Joshua Adedeji
;
Oluwatoyosi, Mercy Adaramodu
;
Orege, Joshua Iseoluwa
;
Ayeni, Emmanuel Ayodeji
;
Ibrahim, Yusuf Ajibola
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/03/29
COVID-19
Therapeutics
Drug interaction
Antiviral drugs
Health and safety
Gene body demethylation increases expression and is associated with self-pruning during grape genome duplication
期刊论文
HORTICULTURE RESEARCH, 2020, 卷号: 7, 期号: 1
作者:
Zou, Luming
;
Liu, Wenwen
;
Zhang, Zhan
;
Edwards, Everard J.
;
Gathunga, Elias Kirabi
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  |  
浏览/下载:28/0
  |  
提交时间:2022/03/01
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:
Zhang, Yu
;
Goto, Masuo
;
Oda, Akifumi
;
Hsu, Pei-Ling
;
Guo, Ling-Li
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2019/07/29
aspidosperma-type
monoterpenoid indole alkaloids
antiproliferative activity
tubulin inhibitor
Bousigonia mekongensis
3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.168, 页码: 426-435
作者:
Min'an Zhai
;
Shiyuan Liu
;
Meiqi Gao
;
Long Wang
;
Jun Sun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Ring tethering
Conformational analysis
Pyrazolo[3,4-b]pyridine
Colchicine site
Synthesis and bioevaluation of diarylpyrazoles as antiproliferative agents
期刊论文
European Journal of Medicinal Chemistry, 2019
作者:
Chao Wang
;
Shuang Yang
;
Jianan Du
;
Jia Ni
;
Yue Wu
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/13
CA-4
Tubulin
Pyrazole
Colchicine
binding
site
Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 170, 页码: 73-86
作者:
Zhao, Wei
;
He, Long
;
Xiang, Tian-Le
;
Tang, Ya-Jie
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Tubulin
Colchicine domain
Podophyllotoxin
Binding affinity
Nanomolar-potency antitumor activity
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties
期刊论文
Investigational New Drugs, 2019
作者:
Wu J.-D.
;
Cui Y.-J.
;
Zhou Y.-G.
;
Tang L.-Q.
;
Zhang C.-M.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Hepatocellular carcinoma
Liver microsome stability
Multidrug-resistance
Pharmacokinetics
Tubulin polymerization inhibitor
Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 7, 页码: 659-664
作者:
Liu, Guangpu
;
Jiao, Yang
;
Huang, Chunxi
;
Chang, Ping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Microtubules inhibitors
Anticancer target
Colchicine binding site
Drug discovery
Molecular docking
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