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上海药物研究所 [49]
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Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease
期刊论文
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2022, 卷号: 59, 期号: 6, 页码: 1086-1101
作者:
Zeng, Y (Zeng, Yan) [1] , [2]
;
Nie, LF (Nie, Lifei) [1]
;
Liu, L (Liu, Liu) [1]
;
Niu, C (Niu, Chao) [1] , [2]
;
Li, Y (Li, Yi) [1] , [2]
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/06/21
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer's disease.
期刊论文
Bioorganic chemistry, 2019, 卷号: Vol.93, 页码: 103328
作者:
Rong Cai
;
Li-Ning Wang
;
Jing-Jing Fan
;
Shang-Qi Geng
;
Yu-Ming Liu
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/11/21
4-N-phenylaminoquinoline
Alzheimer’s disease
Anti-cholinesterase activity
Antioxidant
Metal chelator
Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors
期刊论文
Journal of enzyme inhibition and medicinal chemistry, 2019, 卷号: 34, 页码: 150-162
作者:
Gao Cheng-Zhi[1]
;
Dong Wei[2]
;
Cui Zhi-Wen[3]
;
Yuan Qiong[4]
;
Hu Xia-Min[5]
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  |  
浏览/下载:34/0
  |  
提交时间:2019/04/22
AChE
Alzheimer's Disease
BChE
Olaparib
PARP-1 inhibitor
Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition
期刊论文
DRUG DEVELOPMENT RESEARCH, 2019, 卷号: Vol.80 No.4, 页码: 438-445
作者:
Gao, XH
;
Tang, JJ
;
Liu, HR
;
Liu, LB
;
Liu, YZ
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/17
cholinesterase inhibitors
cinnamic acid
halogen
Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors
期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019, 卷号: 34, 期号: 1
作者:
Gao, Cheng-Zhi
;
Dong, Wei
;
Cui, Zhi-Wen
;
Yuan, Qiong
;
Hu, Xia-Min
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/06
PARP-1 inhibitor
Olaparib
AChE
BChE
Alzheimer's Disease
Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease
期刊论文
ACS chemical neuroscience, 2018
作者:
Wang, Huan
;
Zhang, Haiyan
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  |  
浏览/下载:58/0
  |  
提交时间:2019/01/08
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
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  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer's disease: a network meta-analysis of 41 randomized controlled trials
期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10
作者:
Yu, Jin-Tai
;
Dou, Kai-Xin
;
Tan, Meng-Shan
;
Tan, Chen-Chen
;
Cao, Xi-Peng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Alzheimer's disease
Cholinesterase inhibitors
Memantine
Network meta-analysis
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