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上海药物研究所 [21]
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期刊论文 [103]
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Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
期刊论文
VACCINES, 2020, 卷号: 8, 期号: 3, 页码: 13
作者:
Liu, Dong-qun
;
Lu, Shuai
;
Zhang, Lun
;
Huang, Ya-ru
;
Ji, Mei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/03/29
Alzheimer's disease
beta-amyloid
active immunotherapy
yeast
vaccine
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 4, 页码: 646-666
作者:
Li, Xiaokang
;
Lu, Jian
;
Xu, Yixiang
;
Wang, Jiaying
;
Qiu, Xiaoxia
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Alzheimer's disease
Autophagy
Nitazoxanide
beta-amyloid
Tau protein
Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 144, 页码: 1004-1012
作者:
Zhou, Yue
;
Duan, Yanhong
;
Huang, Shichao
;
Zhou, Xuan
;
Zhou, Lishuang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Lycium barbarum polysaccharides
Alzheimer's disease
Amyloid-beta
Synaptic plasticity
Neuropathology
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice
期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
作者:
Zhang, Xiaochuan
;
Yin, Xianzhen
;
Zhang, Jingjing
;
Li, Anan
;
Gong, Hui
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Micro-Optical Sectioning Tomography
image optimization
Alzheimer's disease
impaired hippocampal vasculature
virtual vascular endoscopy
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1
期刊论文
EXPERIMENTAL NEUROLOGY, 2019, 卷号: 311
作者:
Lu, Mei-Hong
;
Ji, Wen-Li
;
Xu, De-En
;
Yao, Pei-Pei
;
Zhao, Xiu-Yun
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/04
BACE1
Sphingomyelin
Amyloid-beta
Lysosomal degradation
Alzheimer's disease
Lipids
The neuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer's disease
期刊论文
BRAIN STIMULATION, 2019, 卷号: 12, 期号: 1
作者:
Zhou, Zaiying
;
Huang, Dongya
;
Ma, Yu
;
Dai, Chuanfu
;
Ao, Qiang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
Alzheimer's disease
Deep brain stimulation
Nucleus basalis of Meynert
APP/PS1 transgenic mice
Morris water maze
Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.
期刊论文
Neurochemical research, 2019
作者:
Jian Zhou
;
Weihua Yu
;
Man Zhang
;
Xin Tian
;
Yu Li
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/17
Alzheimer’s
disease
Microglia
Systemic
inflammation
TLR4
TREM2
Altered mitochondrial DNA methylation and mitochondrial DNA copy number in an APP/PS1 transgenic mouse model of Alzheimer disease
期刊论文
Biochemical and Biophysical Research Communications, 2019, 卷号: 520, 期号: 1, 页码: 41-46
作者:
Xu Y.
;
Xu L.
;
Han M.
;
Liu X.
;
Li F.
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
12S rRNA gene
Alzheimer's disease
APP/PS1 transgenic mice
D-loop
Mitochondrial DNA copy number
Mitochondrial DNA methylation
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