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Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
收藏
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浏览/下载:17/0
  |  
提交时间:2021/12/16
Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction
期刊论文
ARCHIV DER PHARMAZIE, 2020, 页码: 10
作者:
Xiao, Donghuai
;
Wang, Yu-jie
;
Wang, Han-lin
;
Zhou, Yu-bo
;
Li, Jia
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浏览/下载:26/0
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提交时间:2020/07/01
antitumor
arylboronic acid
lenalidomide
Suzuki cross-coupling
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178, 页码: 782-801
作者:
Wang, Jubo
;
Li, Tinghan
;
Zhao, Tengteng
;
Wu, Tizhi
;
Liu, Chuang
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  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Wogonin
CDK9
AML
Flavonoid
Antitumor
Preclinical characterization of SHR6390, a novel CDK 4/6 inhibitor, invitro and in human tumor xenograft models
期刊论文
CANCER SCIENCE, 2019, 卷号: 110, 期号: 4, 页码: 1420-1430
作者:
Long, Fei
;
He, Ye
;
Fu, Haoyu
;
Li, Yun
;
Bao, Xubin
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  |  
浏览/下载:22/0
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提交时间:2020/07/01
breast cancer
CDK 4/6
drug resistance
palbociclib
SHR6390
Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-like Properties
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 3, 页码: 760-776
作者:
Ding, Chunyong
;
Tian, Qianting
;
Li, Jie
;
Jiao, Mingkun
;
Song, Shanshan
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  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
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浏览/下载:43/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
Design, synthesis, and anticancer properties of isocorydine derivatives
期刊论文
Bioorganic and Medicinal Chemistry, 2017, 卷号: 25, 期号: 24, 页码: 6542-6553
作者:
Yan, Qian
;
Di DL(邸多隆)
;
Li, Wenguang
;
Liu JX(柳军玺)
;
Zhang YX(张燕霞)
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  |  
浏览/下载:25/0
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提交时间:2018/06/20
Isocorydine
Aporphine Alkaloid
Structure Modification
Anticancer Activity
Hepatocellular Carcinoma
Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 22, 页码: 5399-5402
作者:
Han, Mei
;
Wang, Chengyan
;
Ji, Yinchun
;
Song, Zilan
;
Xing, Li
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  |  
浏览/下载:66/0
  |  
提交时间:2019/01/08
EML4-ALK kinase
Oxidative metabolism
Benzo[b]carbazolone
hERG
Antitumor activity
Dietary apigenin potentiates the inhibitory effect of interferon-alpha on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation
期刊论文
FOOD & NUTRITION RESEARCH, 2016, 卷号: 60, 页码: 31288(1-12)
作者:
He, YJ
;
Yang, LJ
;
Li, S
;
Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4 Renmin South Rd, Chengdu 610041, Peoples R China.
;
Wang, F
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  |  
浏览/下载:20/0
  |  
提交时间:2017/11/09
Apigenin
Interferon
Proteasome
Stat
Ubiquitination
Discovery of phenylpiperazine derivatives as IGF-1R inhibitor with potent antiproliferative properties in vitro
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 25, 期号: 5, 页码: 1067-1071
作者:
Guo, Feng-Jiao
;
Sun, Juan
;
Gao, Li-Li
;
Wang, Xin-Yi
;
Zhang, Yang
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
Phenylpiperazine
IGF-1R inhibitors
Apoptosis
Computer simulation
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