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上海药物研究所 [20]
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期刊论文 [68]
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Gefitinib enhances the anti-tumor immune response against EGFR-mutated NSCLC by upregulating B7H5 expression and activating T cells via CD28H
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2022, 卷号: 61
作者:
Guo, Huihui
;
Zhang, Xilin
;
Xie, Shangzhi
;
Chen, Tianwei
;
Xie, Dong
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/22
gefitinib
CD28H
NSCLC
EGFR mutation
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis
期刊论文
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 12
作者:
Liao, Min
;
Dong, Qiongye
;
Chen, Ruiqing
;
Xu, Liqian
;
Jiang, Yuxuan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/12/01
Transcriptome Regulation by Oncogenic ALK Pathway in Mammalian Cortical Development Revealed by Single-Cell RNA Sequencing
期刊论文
CEREBRAL CORTEX, 2021, 卷号: 31, 期号: 8, 页码: 3911-3924
作者:
Mao, Rui
;
Zhang, Xiaoyun
;
Kong, Youyong
;
Wu, Shanshan
;
Huo, Hai-qin
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
anaplastic lymphoma kinase
cerebral organoid
neurodevelopment
neural progenitor cell
single-cell RNA sequencing
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Jiang, Jin-fang
;
Yang, Yong
;
Guo, Li-xia
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Alflutinib
Rifampicin
CYP3A4
AST5902
Drug-drug interaction
A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters
期刊论文
ACS CHEMICAL BIOLOGY, 2020, 卷号: 15, 期号: 9, 页码: 2551-2557
作者:
Zhang, Qian
;
Ren, Jin-Wei
;
Wang, Weishan
;
Zhai, Ji'an
;
Yang, Jing
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/17
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer
期刊论文
CANCER CELL, 2020, 卷号: 38, 期号: 1, 页码: 115-+
作者:
Tang, Yang
;
Fang, Gemin
;
Guo, Fenghua
;
Zhang, Hui
;
Chen, Xiaoxu
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2020/12/24
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer (NSCLC)
EGFR T790M
Small-molecule inhibitor
Drug resistance
Ack1
PD-L1 expression and T cells infiltration in patients with uncommon EGFR-mutant non-small cell lung cancer and the response to immunotherapy
期刊论文
LUNG CANCER, 2020, 卷号: 142
作者:
Chen, Kaiyan
;
Cheng, Guoping
;
Zhang, Fanrong
;
Zhu, Guanxia
;
Xu, Yanjun
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/11/26
Uncommon EGFR
Non-small cell lung cancer
PD-L1
T cell
Immunotherapy
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