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上海药物研究所 [13]
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期刊论文 [52]
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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263
作者:
Elksnis, Andris
;
Schiffer, Tomas A.
;
Palm, Fredrik
;
Wang, Yun
;
Cen, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 4, 页码: 483-498
作者:
Xu, Ming-ming
;
Ryan, Philip
;
Rudrawar, Santosh
;
Quinn, Ronald J.
;
Zhang, Hai-yan
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  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
imaging probes
aggregation inhibitors
thioflavin-T
mass spectrometry
Discovery and Biological Evaluation of New Selective Acetylcholinesterase Inhibitors with Anti-A beta Aggregation Activity through Molecular Docking-Based Virtual Screening
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 2, 页码: 161-166
作者:
Liu, Guangpu
;
Jiao, Yang
;
Lin, Yongqiang
;
Hao, Haifang
;
Dou, Yanli
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
selective acetylcholinesterase inhibitor
amyloid beta aggregation
neuroprotectant
molecular docking
molecular dynamics simulation
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 183, 页码: 111737
作者:
Bai, Ping
;
Wang, Keren
;
Zhang, Pengfei
;
Shi, Jian
;
Cheng, Xinfeng
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  |  
浏览/下载:10/0
  |  
提交时间:2021/11/04
Alzheimer's disease
Chalcone-O-Alkylamine derivatives
Multi-functional agents
Rational design
Synthesis
Precognitive effect
Inhibition of lysozyme fibrillation by gold nanorods and nanoparticles
期刊论文
Journal of nanoscience and nanotechnology, 2018, 卷号: 18, 期号: 5, 页码: 3087-3094
作者:
Liang, Hongli
;
Wang, Bing
;
Wang, Hailong
;
Yu, Miao
;
Zheng, Lingna
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  |  
浏览/下载:41/0
  |  
提交时间:2019/04/23
Gold nanorods and nanoparticles
Lysozyme fibrillation
Inhibition effects
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
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  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid-beta aggregation inhibition
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 76
作者:
Lan, Jin-Shuai
;
Liu, Yun
;
Hou, Jian-wei
;
Yang, Jing
;
Zhang, Xin-Yu
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Monoamine oxidase
A beta (1-42) aggregation
Alzheimer's disease
Molecular docking
Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles
期刊论文
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2018, 卷号: 18, 期号: 5, 页码: 3087-3094
作者:
Liang, HL
;
Feng, WY
;
Zhang, AP
;
Wang, M
;
Zheng, LN
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/09/24
Gold Nanorods and Nanoparticles
Lysozyme Fibrillation
Inhibition Effects
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and beta-amyloid aggregation inhibitory activities as potential agents against Alzheimer\'s disease
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: Vol.26 No.8, 页码: 1885-1895
作者:
Xu, R
;
Xiao, GY
;
Li, Y
;
Liu, HY
;
Song, Q
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
Alzheimer\'s disease
Benzo[d]isothiazol-3(2H)-one derivatives
Monoamine oxidase inhibitors
Acetylcholinesterase inhibitors
A beta aggregation inhibitors
Multifunctional agents
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