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CORC

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Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold 期刊论文
2019, 卷号: 27, 期号: 8, 页码: 1562-1576
作者:  Yin, Yuan;  Chen, Cheng-Juan;  Yu, Ru-Nan;  Shu, Lei;  Zhang, Tian-Tai
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/03
Discovery of N 1--7 H -pyrrolo[2,3- d] pyrimidin-2-yl)amino)phenyl)- N 8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 and Histone Deacetlyase1 against Malignant Cancer 期刊论文
Journal of Medicinal Chemistry, 2018, 卷号: Vol.61 No.7, 页码: 3166-3192
作者:  Li, Y.;  Luo, X.;  Guo, Q.;  Nie, Y.;  Wang, T.
收藏  |  浏览/下载：4/0  |  提交时间：2019/02/25
Solvent-free synthesis and antiviral activity of chiral dialkyl 2-(substituted-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl) malonate 期刊论文
2018, 期号: 8, 页码: 428-433
作者:  Bai, Song;  Liu, Shan;  Zhu, Yunying;  Lu, Jiali;  Ai, Lina
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/02
Structure-based design and synthesis of 1H-pyrazolo[3,4-d]pyrimidin-4-amino derivatives as Janus kinase 3 inhibitors 期刊论文
2018, 卷号: 26, 期号: 17, 页码: 4774-4786
作者:  Yin, Yuan;  Chen, Cheng-Juan;  Yu, Ru-Nan;  Wang, Zhi-Jian;  Zhang, Tian-Tai
收藏  |  浏览/下载：6/0  |  提交时间：2020/01/03
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping
收藏  |  浏览/下载：42/0  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan
收藏  |  浏览/下载：689/0  |  提交时间：2018/08/17
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E
收藏  |  浏览/下载：34/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E
收藏  |  浏览/下载：41/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E
收藏  |  浏览/下载：33/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E
收藏  |  浏览/下载：30/0  |  提交时间：2018/07/26

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