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Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
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  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
Design, Synthesis, and Biological Activities of Novel Triazolothiadiazole Derivatives Linked with Amino Side Chain Containing Urea Group as DOT1L Inhibitors
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 8, 页码: 2450-2459
作者:
Liu Na
;
Guo Siqi
;
Liu Junfang
;
Chen Yantao
;
Xu Xiaoming
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  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
triazolothiadiazole
triazolothiadiazine
nucleophilic substitution
Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 5, 页码: 1345-1354
作者:
Xu Xiaoming
;
Guo Siqi
;
Zhang Jing
;
Chen Yantao
;
Kang Yaqing
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  |  
浏览/下载:18/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
ttriazolo-thiadiazole
structural modification
hydrophobic substituent
structure-activity analysis
2Ch-2N square and hexagon interactions: a combined crystallographic data analysis and computational study
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2019, 卷号: 21, 期号: 38, 页码: 21568-21576
作者:
Lu, Yunxiang
;
Li, Wenxia
;
Yang, Weiwei
;
Zhu, Zhengdan
;
Xu, Zhijian
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  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Facile Synthesis of [1,2,4]Triazolo[4,3-a]pyrazin-3-amines via Oxidative Cyclization of 1-guanidine Derivatives
期刊论文
Transactions of Tianjin University, 2019, 卷号: Vol.25 No.2, 页码: 185-194
作者:
Li, W.
;
Kang, J.
;
Zhou, X.
;
Liu, D.
;
Sun, H.
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  |  
浏览/下载:4/0
  |  
提交时间:2019/11/21
1-(Pyrazin-2-yl)guanidines
Cyclization
Synthesis
Triazolopyrazines
[1,2,4]Triazolo[4,3-a]pyrazin-3-amines
Urea and thiourea derivatives of 3--5,6,7,8-tetrahydro-[1, 2, 4]triazolo[4,3-a]pyrazine: Synthesis, characterization, antimicrobial activity and docking studies.
期刊论文
Phosphorus, Sulfur & Silicon & the Related Elements, 2019, 卷号: Vol.194 No.9, 页码: 922-932
作者:
Mannam, Madhava Rao
;
Devineni, Subba Rao
;
Pavuluri, Chandra Mouli
;
Chamarthi, Naga Raju
;
Kottapalli, Raja Sekhara P
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浏览/下载:7/0
  |  
提交时间:2019/11/21
adenosine-5-diphosphoribose enzyme
antimicrobial activity
molecular docking
sitagliptin intermediate
structural characterization
Urea and thiourea derivatives
The Diverse supramolecular synthons formed by 2-subsituted 5-morpholinomethylphenyl Triazolo[1,5-a]pyridines in solid state
期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2019, 卷号: Vol.1176, 页码: 149-156
作者:
Chai, Yingying
;
Li, Changfu
;
Meng, Liying
;
Zhou, Xinglong
;
Xia, Zhenqiang
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  |  
浏览/下载:52/0
  |  
提交时间:2019/02/25
1,2,4-triazolo[1,5-a]pyridine
Supramolecular synthons
Inductive effect
Crystal structure
Oxidative C(sp(3))-H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines.
期刊论文
Organic & biomolecular chemistry, 2019, 卷号: 17, 期号: 8, 页码: 2087-2091
作者:
Weng, Wei-Zhao
;
Gao, Yin-He
;
Zhang, Xue
;
Liu, Yan-Hua
;
Shen, Ying-Jie
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/23
ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia
期刊论文
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 卷号: 45, 期号: 12, 页码: 1257-1264
作者:
Zhou, Tingting
;
Du, Mengfan
;
Zhao, Tong
;
Quan, Lingling
;
Zhu, Zhiyuan
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  |  
浏览/下载:94/0
  |  
提交时间:2019/01/08
beta cell
apoptosis
glucose-stimulated insulin secretion
T2DM
Choice of hydrogen bonds or halogen bonds by 2-halogenated 5-morpholinomethylphenyl triazolo[1,5-a]pyridine
期刊论文
CrystEngComm, 2018, 卷号: Vol.20 No.22, 页码: 3006-3010
作者:
Li, CF
;
Chai, YY
;
Zhou, XL
;
Shen, Z
;
Ma, BB
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  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
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