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科研机构
上海药物研究所 [3]
大连化学物理研究所 [3]
昆明医科大学 [2]
自然资源部第一海洋研... [2]
清华大学 [1]
北京大学 [1]
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期刊论文 [18]
发表日期
2019 [3]
2018 [3]
2016 [1]
2014 [1]
2013 [1]
2012 [1]
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Cell Biolo... [1]
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Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 12
作者:
Huang, Huili
;
Xie, Ming
;
Gao, Li
;
Zhang, Wenhui
;
Zhu, Xiaojia
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/06/20
PDE4
rolipram
P-V loop
Ca2+ transient
SERCA2a
Rolipram, a pde4 inhibitor, enhances the inotropic effect of rat heart by activating serca2a
期刊论文
Frontiers in pharmacology, 2019, 卷号: 10, 页码: 12
作者:
Huang, Huili
;
Xie, Ming
;
Gao, Li
;
Zhang, Wenhui
;
Zhu, Xiaojia
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2019/05/08
Pde4
Rolipram
P-v loop
Ca2+ transient
Serca2a
PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2019, 卷号: 9, 期号: 9, 页码: 1905-+
作者:
An, Ran
;
Liu, Jueyu
;
He, Jing
;
Wang, Fei
;
Zhang, Qing
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
Anagrelide
PDE3A
SLFN12
cancer
cytokine
Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors
期刊论文
JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM, 2018, 卷号: 98, 期号: 2, 页码: 333-339
作者:
Liang, Xiao
;
Chen, Yu-Ru
;
Gao, Wei
;
Guo, Xing-Pan
;
Ding, De-Wen
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/08/19
Mytilus coruscus
larval metamorphosis
pharmacological compounds
G protein-coupled receptor
Effects on larval metamorphosis in the mussel Mytilus coruscus of compounds that act on downstream effectors of G-protein-coupled receptors
期刊论文
JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM, 2018, 卷号: 98, 期号: 2, 页码: 333-339
作者:
Liang, Xiao
;
Chen, Yu-Ru
;
Gao, Wei
;
Guo, Xing-Pan
;
Ding, De-Wen
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2018/12/07
Mytilus coruscus
larval metamorphosis
pharmacological compounds
G protein-coupled receptor
Myelin injury in the central nervous system and Alzheimer's disease
期刊论文
Brain Research Bulletin, 2018, 卷号: 140, 页码: 162-168
作者:
Wang, Sha-Sha
;
Zhang, Zhao
;
Zhu, Tian-Bi
;
Chu, Shi-Feng
;
He, Wen-Bin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/27
OLG
oligodendrocyte
CNS
central nervous system
SC
Schwann cell
PNS
peripheral nervous system
MBP
myelin basic protein
PLP
proteolipid protein
P0/MPZ
myelin protein zero
EAE
experimental allergic encephalomyelitis
MS
multiple sclerosis
CNP
2′ 3′-cyclic nucleotide 3′-phosphodiesterase
MAG
myelin associated glycoprotein
MOG
myelin oligodendrocyte glycoprotein
AD
Alzheimer's disease
OPC
oligodendrocyte precursor cell
NPC
neural progenitor cell
ROS
reactive oxygen species
TNF
tumour necrosis factor
AIF
apoptosis-inducing factor
IFN-γ
interferon gamma
ERK1/2
extracellular signal-regulated kinases-1 and -2
MAPK
mediators of mitogen-activated protein kinase
FGFR1/2
fibroblast growth factor receptors-1 and -2
Dock3
dedicator of cytokinesis 3
PERK
pancreatic endoplasmic reticulum kinase
GEF
guanine nucleotide exchange factor
SIRT2
sirtuin 2
NOD2
Nucleotide-binding oligomerization domain containing protein 2
RIPK2
receptor-interacting serine/threonine kinase 2
Shh
Sonic Hedgehog
NMO
neuromyelitis optica
ADEM
acute disseminated encephalomyelitis
ANHLE
acute necrotizing hemorrhagic leukoencephalitis
CPM
central pontine myelinolysis
Aβ
beta-amyloid
SP
senile plaque
NFT
neurofibrillary tangle
MRI
magnetic resonance imaging
Myelin
Oligodendrocyte
Demyelination
Neurodegenerative diseases
Alzheimer’s disease
PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction
期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2016
作者:
Knight Walter E[1]
;
Chen Si[2]
;
Zhang Yishuai[3]
;
Oikawa Masayoshi[4]
;
Wu Meiping[5]
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/04/26
cardiac remodeling
cyclic nucleotide
heart failure
phosphodiesterase
Expression of 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro
期刊论文
JOURNAL OF NEUROINFLAMMATION, 2014, 卷号: 11
作者:
Yang, Lijuan
;
Kan, Enci Mary
;
Lu, Jia
;
Wu, Chunyun
;
Ling, Eng-Ang
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/04
CNPase
Activated microglia
Lipopolysaccharide
Inflammatory mediators
Anti-inflammation
Inhibition mechanism exploration of quinoline derivatives as PDE10A inhibitors by in silico analysis
期刊论文
molecular biosystems, 2013, 卷号: 9, 期号: 3, 页码: 386-397
作者:
Wu, Qian
;
Gao, Qingping
;
Guo, Huanmei
;
Li, Dan
;
Wang, Jinghui
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2015/11/09
Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 55, 期号: 23, 页码: 10540-10550
作者:
Wang, Guan
;
Liu, Zheng
;
Chen, Tiantian
;
Wang, Zhen
;
Yang, Huaiyu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
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