QQ客服 官方微博 反馈留言

浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Recent Trends and Applications of Molecular Modeling in GPCR-Ligand Recognition and Structure-Based Drug Design 期刊论文 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 7 作者:  Yuan, Xiaojing;  Xu, Yechun 收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 GPCR  receptor-ligand recognition  drug design  molecular modeling  molecular dynamics  docking  binding affinity  binding pathway   Synthesis and Cell Division Cycle 25B Phosphatase/Protein Tyrosine Phosphatase 1B Inhibitory Activity Evaluation of Novel Acylthiourea Derivatives 期刊论文 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 5, 页码: 1242-1250 作者:  Li Yingjun;  Wang Siyuan;  Jin Kun;  Gao Lixin;  Sheng Li 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 acylthiourea  carbazole  synthesis  Cdc25B and PTP1B inhibitors  molecular docking   Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai;  Jiang, Chengshi;  Tao, Hongrui;  Liu, Jingqiu;  Zhang, Hua 收藏  |  浏览/下载：59/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Zhang, Guoqing;  Xing, Jing;  Wang, Yulan;  Wang, Lihao;  Ye, Yan 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 indoleamine 2, 3-dioxygense  IDO1 inhibitor  virtual screening  molecular docking  hit expansion   H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo 期刊论文 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 卷号: 341, 页码: 98-105 作者:  Yang, Yanting;  Guan, Daokun;  Lei, Lei;  Lu, Jing;  Liu, Jia Qi 收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 alpha-Hederagenin  H6  Multidrug resistance  P-glycoprotein  Molecular docking   Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727 作者:  Zhu, Kongkai;  Jiang, Cheng-Shi;  Hu, Junchi;  Liu, Xigong;  Yan, Xue 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 PRMT5 SAM competitive inhibitor  Molecular docking  Molecular dynamics simulation  Molecular mechanics/Poisson-Boltzmann surface area  PRMT5:MEP50 interaction   Parallelization of Molecular Docking: A Review 期刊论文 CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2018, 卷号: 18, 期号: 12, 页码: 1015-1028 作者:  Dong, Dong;  Xu, Zhijian;  Wu, Zhong;  Peng, Shaoliang 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Molecular docking  virtual screening  high-performance computing   artificialintelligenceindrugdesign 期刊论文 sciencechinalifesciences, 2018, 卷号: 61, 期号: 10, 页码: 1191 作者:  Zhong Feisheng;  Xing Jing;  Li Xutong;  Liu Xiaohong;  Fu Zunyun 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 PROTEIN-PROTEIN-INTERACTION  MACHINE LEARNING-METHODS  COMPUTATIONAL METHODS  MOLECULAR-PROPERTIES  INTERACTION NETWORKS  NEURAL-NETWORKS  PREDICTION  DOCKING  DISCOVERY  PERMEABILITY  drug design  artificial intelligence  deep learning  QSAR  ADME/T