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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270 作者:  Zhang, Wei-yao;  Lu, Wen-chao;  Jiang, Hao;  Lv, Zheng-bing;  Xie, Yi-qian 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 epigenetics  molecular docking  PRMT1  scaffold hopping  small-molecule inhibitor   Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531 作者:  Chen, Wenhua;  Guo, Ne;  Qi, Minghui;  Dai, Haiying;  Hong, Minghuang 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Antitumor drug  BRCA1/2  PARP inhibitors  Molecular docking   Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 598-611 作者:  Qian, Hai-Yan;  Wang, Zhi-Long;  Xie, Xiao-Yu;  Pan, You-Lu;  Li, Gang-Jian 收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 Pyridazine-3-carboxamides  CB2 agonist  Structure-activity relationships  Molecular docking  logP   Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf(V600E) inhibitors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1059-1068 作者:  Wang, Gui-min;  Wang, Xiang;  Zhu, Jian-ming;  Guo, Bin-bin;  Yang, Zhuo 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 B-Raf(V600E) inhibitor  anticancer  vemurafenib  deazapurine  fragment reassembly  molecular docking  structure-activity relationship   Characterization, Molecular Docking, and In Vitro Dissolution Studies of Solid Dispersions of 20(S)-Protopanaxadiol 期刊论文 MOLECULES, 2017, 卷号: 22, 期号: 2 作者:  Zhang, Qi;  Pu, Yiqiong;  Wang, Bing;  Wang, Yuqin;  Dong, Tina Tingxia 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 20(S)-protopanaxadiol  solid dispersion  polymer  molecular docking  in vitro dissolution   Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 2, 页码: 342-346 作者:  Shao, Zhiyuan;  Xu, Pan;  Xu, Wen;  Li, Linjuan;  Liu, Shien 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Epigenetics  DNMT3A inhibitors  Virtual screening  Molecular docking   Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide 期刊论文 JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 卷号: 19, 期号: 12, 页码: 1204-1213 作者:  Jiang, Cheng-Shi;  Zhang, Li;  Gong, Jing-Xu;  Li, Jing-Ya;  Yao, Li-Gong 收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 Synthesis  dihydroresorcylide  PTP1B inhibitory activity  molecular docking   Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors 期刊论文 ARCHIV DER PHARMAZIE, 2017, 卷号: 350, 期号: 1 作者:  Jing, Changcheng;  Li, Ziyan;  Jia, Kaili;  Chen, Chen;  Liu, Xiao 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Inhibitor  Mixed 3,3 '-bisindoles  Molecular docking  Protein tyrosine phosphatase 1B   Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf~(V600E) inhibitors 期刊论文 Acta Pharmacologica Sinica, 2017, 卷号: 38, 期号: 7, 页码: 1057-1068 作者:  Wang Guimin;  Wang Xiang;  Zhu Jianming;  Guo Binbin;  Yang Zhuo 收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 B-Raf~(V600E) inhibitor  anticancer  vemurafenib  deazapurine  fragment reassembly  molecular docking  structure-activity relationship