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SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade 期刊论文
EMBO JOURNAL, 2021, 页码: 16
作者:  Wang, Xu;  Ni, Jiahui;  You, Yan;  Feng, Guize;  Zhang, Sulin
收藏  |  浏览/下载:37/0  |  提交时间:2021/12/16
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1337-1360
作者:  Yang, Yaxi;  Zhang, Rukang;  Li, Zhaojun;  Mei, Lianghe;  Wan, Shili
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/01
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
作者:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/01
Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 17, 页码: 3648-3661
作者:  Ye, Yan;  Zhang, Bidong;  Mao, Ruifeng;  Zhang, Chenhua;  Wang, Yulan
收藏  |  浏览/下载:22/0  |  提交时间:2019/01/08
Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2973-2982
作者:  Xu, Yuan;  Li, Liang;  Wang, Yulan;  Xing, Jing;  Zhou, Lei
收藏  |  浏览/下载:12/0  |  提交时间:2019/01/08
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase 期刊论文
ACTA PHARMACEUTICA SINICA B, 2016, 卷号: 6, 期号: 1, 页码: 32-45
作者:  Zhou, Yu;  Liu, Jun;  Zheng, Mingyue;  Zheng, Shuli;  Jiang, Chunyi
收藏  |  浏览/下载:21/0  |  提交时间:2019/01/08
structuraloptimizationandbiologicalevaluationofl5disubstitutedpyrazole3carboxaminesaspotentinhibitorsofhuman5lipoxygenase 期刊论文
actapharmaceuticasinicab, 2016, 卷号: 6, 期号: 1, 页码: 32
作者:  Zhou Yu;  Liu Jun;  Zheng Mingyue;  Zheng Shuli;  Jiang Chunyi
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/01
Structural optimization and biological evaluation of l,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase 期刊论文
Acta Pharmaceutica Sinica B, 2016, 卷号: 6, 期号: 1, 页码: 32
作者:  Zhou Yu;  Liu Jun;  Zheng Mingyue;  Zheng Shuli;  Jiang Chunyi
收藏  |  浏览/下载:20/0  |  提交时间:2020/12/24
In silico ADME/T modelling for rational drug design 期刊论文
QUARTERLY REVIEWS OF BIOPHYSICS, 2015, 卷号: 48, 期号: 4, 页码: 488-515
作者:  Wang, Yulan;  Xing, Jing;  Xu, Yuan;  Zhou, Nannan;  Peng, Jianlong
收藏  |  浏览/下载:11/0  |  提交时间:2019/01/08
Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 20, 页码: 8166-8181
作者:  Meng, Fanwang;  Cheng, Sufang;  Ding, Hong;  Liu, Shien;  Liu, Yan
收藏  |  浏览/下载:30/0  |  提交时间:2019/01/08


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