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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
发表日期
2018 [1]
2017 [2]
2016 [1]
2014 [1]
2011 [2]
2010 [2]
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专题:上海药物研究所
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Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47
作者:
Xu, Yi-xiang
;
Wang, Huan
;
Li, Xiao-kang
;
Dong, Sheng-nan
;
Liu, Wen-wen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
MAO-B inhibitors
Metal chelating agents
Alzheimer's disease
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531
作者:
Chen, Wenhua
;
Guo, Ne
;
Qi, Minghui
;
Dai, Haiying
;
Hong, Minghuang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Antitumor drug
BRCA1/2
PARP inhibitors
Molecular docking
The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 127, 页码: 424-433
作者:
Wang, Jing
;
Yang, Teng
;
Chen, Huang
;
Xu, Yun-Nan
;
Yu, Li-Fang
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Berberine derivatives
Antistaphylococcal activity
Multidrug-resistant
Cytotoxicity
Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 卷号: 10, 页码: 357-370
作者:
Zhang, Yi-fan
;
Dai, Xiao-jian
;
Yang, Yong
;
Chen, Xiao-yan
;
Wang, Ting
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
nemonoxacin
probenecid
cimetidine
clinical pharmacokinetics
drug-drug interaction
Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver (I)
期刊论文
SCIENTIFIC REPORTS, 2014, 卷号: 4
作者:
Shi, De-Tai
;
Wei, Xiao-Li
;
Sheng, Yayun
;
Zang, Yi
;
He, Xiao-Peng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Synthesis and evaluation of kappa-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7 alpha-phenyl-6 alpha,14 alpha-endo-etheno-tetrahydrothebaine with substituted o-, m- and p-amino group
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2011, 卷号: 20, 期号: 8, 页码: 1364-1370
作者:
Qi, Hong
;
Li, Wei
;
Qiu, Yu
;
Cui, Yong-yao
;
Ma, Jian
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
kappa-Opioid receptor
Opioid agonist
Antinociception
Identification of small molecular inhibitors for Ero1p by structure-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 卷号: 21, 期号: 4, 页码: 1118-1121
作者:
Chu, Yanyan
;
Chen, Xianjun
;
Yang, Yi
;
Tang, Yun
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Virtual screening
Ero1p
Disulfide bond
Protein disorder
Oxidoreductase
Characterization of the Multiple Absorbed Constituents in Rats after Oral Administration of Chai-Huang Decoction by Liquid Chromatography Coupled with Electrospray-Ionization Mass Spectrometry
期刊论文
CHEMISTRY & BIODIVERSITY, 2010, 卷号: 7, 期号: 12, 页码: 2917-2930
作者:
Ye, Guan
;
Tang, Yi-Hong
;
Wang, Gui-Yun
;
Li, Zhi-Xiong
;
Zhu, Hai-Yan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 卷号: 20, 期号: 1, 页码: 418-421
作者:
Li, Wei
;
Tao, Yi-Min
;
Tang, Yun
;
Xu, Xue-Jun
;
Chen, Jie
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
mu Opioid agonists
Selective ligands
Oripavines
Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 卷号: 570, 期号: 1-3, 页码: 125-134
作者:
Yang, Yun-Bo
;
Yang, Yi-Xin
;
Su, Bo
;
Tang, Yun-Lian
;
Zhu, Bing-Yang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Probucol
vascular remodeling
ERK1/2
VSMC
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