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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/06/28
Thermal Emitting Strategy to Synthesize Atomically Dispersed Pt Metal Sites from Bulk Pt Metal
期刊论文
Journal of the American Chemical Society, 2019, 卷号: 141, 页码: 4505-4509
作者:
Qu Yunteng[1]
;
Chen Bingxu[2]
;
Li Zhijun[3]
;
Duan Xuezhi[4]
;
Wang Liguang[5]
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  |  
浏览/下载:98/0
  |  
提交时间:2019/04/22
Unknown disturbance estimation for vibration systems using distributed piezoelectric sensors
期刊论文
MECHANICS & INDUSTRY, 2019, 卷号: 19
作者:
Wu, Bin-Yi[1]
;
Qin, Xian-Sheng[2]
;
Zhang, Shun-Qi[3]
;
Bai, Jing[4]
;
Xue, Ting[5]
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/04/22
Disturbance observation
proportional-integral observer
smart structures
distributed piezoelectric sensors
Stacking of Tailored Chalcogenide Nanosheets around MoO2-C Conductive Stakes Modulated by a Hybrid POM subset of MOF Precursor Template: Composite Conversion-Insertion Cathodes for Rechargeable Mg-Li Dual-Salt Batteries
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2019, 卷号: 11, 页码: 5966-5977
作者:
Wu, Chenglong[1]
;
Hu, Jiulin[2]
;
Tian, Jing[3]
;
Chu, Fulu[4]
;
Yao, Zhenguo[5]
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  |  
浏览/下载:39/0
  |  
提交时间:2019/04/22
Mg-Li dual-salt electrolyte
POM
MOF
NENU-5
chalcogenide cathodes
Mg-based batteries
Impact of PHEV in active distribution network under gas station network attack
期刊论文
ISA transactions, 2019
作者:
Li Xue[1]
;
Dong Jing[2]
;
Du Dajun[3]
;
Wu Lei[4]
;
Fei Minrui[5]
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/04/22
Attack
Correlation
Elementary transformation (ET)
Gas station network
Nataf/normalization transformation
Plug-in hybrid electric vehicle (PHEV)
Point estimate method (PEM)
Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus
期刊论文
Progress in neuro-psychopharmacology & biological psychiatry, 2019, 卷号: 93, 页码: 11-20
作者:
Han Qiu-Qin[1]
;
Huang Hui-Jie[2]
;
Wang Ya-Lin[3]
;
Yang Liu[4]
;
Pilot Adam[5]
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  |  
浏览/下载:46/0
  |  
提交时间:2019/04/22
Chronic social defeat stress (CSDS)
Depression
Ghrelin
P38
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats
期刊论文
Biomedicine & pharmacotherapy, 2019, 卷号: 112, 页码: 108701
作者:
Zheng Min[1]
;
Li Yuan-Yuan[2]
;
Wang Guo-Feng[3]
;
Jin Jing-Yi[4]
;
Wang Ya-Hang[5]
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  |  
浏览/下载:24/0
  |  
提交时间:2019/04/22
Cultured bear bile powder
Dimethylnitrosamine
Liver fibrosis
Metabolomics
Cytotoxicity comparison between fine particles emitted from the combustion of municipal solid waste and biomass
期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2019, 卷号: 367, 页码: 316-324
作者:
Shang, Yu[1]
;
Wu, Meiying[2]
;
Zhou, Jizhi[3]
;
Zhang, Xing[4]
;
Zhong, Yufang[5]
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/04/22
Municipal solid waste incineration
Biomass incineration
PM2.5
Cytotoxicity
Oxidative stress
20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway
期刊论文
Journal of cellular biochemistry, 2019, 卷号: 120, 页码: 5085-5096
作者:
Wang Xue[1]
;
Xia Hua-Ying[2]
;
Qin Hong-You[3]
;
Kang Xiang-Ping[4]
;
Hu Hai-Yan[5]
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/04/22
ATF4
apoptosis
endoplasmic reticulum stress (ER stress)
human umbilical vein endothelial cells (HUVECs)
protein kinase R-like endoplasmic reticulum kinase (PERK)
protopanaxadiol (PPD)
small interfering RNA (siRNA)
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
Frontiers in pharmacology, 2019, 卷号: 10, 页码: 52
作者:
Dai Zi-Ru[1]
;
Ning Jing[2]
;
Sun Gui-Bo[3]
;
Wang Ping[4]
;
Zhang Feng[5]
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/04/22
bufotalin
cytochrome P450 3A (CYP3A)
docking simulations
human liver microsomes (HLMs)
hydroxylation
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