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浏览/检索结果: 共16条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14 作者:  He, Yu-Long;  Chen, Meng-Ting;  Wang, Ting;  Zhang, Ming-Ming;  Li, Ying-Xia 收藏  |  浏览/下载：64/0  |  提交时间：2021/11/04 Type 2 diabetes mellitus  Dual FABP4/5 inhibitors  Anti-lipolytic and anti-inflammatory effects  Metabolic stability  Anti-diabetic activities   Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice 期刊论文 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 379, 期号: 2, 页码: 125-133 作者:  Han, Li;  Ma, Chenhui;  Peng, Huige;  Wu, Zhitao;  Xu, Huiming 收藏  |  浏览/下载：27/0  |  提交时间：2022/01/04 Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen 收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14822-14847 作者:  Wei, Dan;  Wang, Hanlin;  Zeng, Qinghe;  Wang, Wenjing;  Hao, Bingbing 收藏  |  浏览/下载：30/0  |  提交时间：2021/12/16 Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663 作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong 收藏  |  浏览/下载：17/0  |  提交时间：2021/12/16 Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199 作者:  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Liang, Xiaoying;  Lan, Yuan 收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04 Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Liu, Lu;  Li, Wei;  Yang, Le;  Guo, Zi-tao;  Xue, Hao 收藏  |  浏览/下载：78/0  |  提交时间：2021/08/17 almonertinib  itraconazole  rifampicin  drug metabolism  drug interaction  CYP3A  P-gp  pharmacokinetics   Synthesis and biological evaluation of novel cabazitaxel analogues 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 41, 页码: 12 作者:  Ren, Sumei;  Zhang, Minmin;  Wang, Yujie;  Guo, Jia;  Wang, Junfei 收藏  |  浏览/下载：62/0  |  提交时间：2021/08/17 Tritium extraction  Hydrogen isotopes  Eutectic Pb-Li  Fusion fuel cycle  Cabazitaxel  Docetaxel  Taxel  Anticancer  Semi-synthesis  10-Deacetylbaccatin III  Cytotoxicity   Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14 作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei 收藏  |  浏览/下载：40/0  |  提交时间：2021/08/17 SHP2 degradation  Proteolysis targeting chimera (PROTAC)  Thalidomide-based heterobifunctional molecules  E3 ubiquitin ligase  CRBN