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科研机构
上海药物研究所 [22]
内容类型
期刊论文 [22]
发表日期
2021 [22]
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共22条,第1-10条
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发表日期:2021
专题:上海药物研究所
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence
期刊论文
CELL REPORTS, 2021, 卷号: 37, 期号: 5, 页码: 21
作者:
Zan, Gui-Ying
;
Wang, Yu-Jun
;
Li, Xue-Ping
;
Fang, Jun-Fan
;
Yao, Song-Yu
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/12/16
A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
期刊论文
MOLECULAR CELL, 2021, 卷号: 81, 期号: 19, 页码: 4076-+
作者:
Liu, Zhiwei
;
Liu, Yingluo
;
Qian, Lili
;
Jiang, Shangwen
;
Gai, Xiameng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/12/01
Imatinib inhibits the malignancy of hepatocellular carcinoma by suppressing autophagy
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 906, 页码: 8
作者:
Xiao, Meng-Chao
;
Qian, Hui
;
Huang, Chen-Kai
;
Zheng, Bai-Nan
;
Yan, Fang-Zhi
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/11/04
Imatinib
Autophagy
Hepatocarcinoma
Sorafenib
Synergetic effect
Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 14
作者:
Feng, Mei
;
Wu, Zhongen
;
Zhou, Yan
;
Wei, Zhuang
;
Tian, Enming
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/04
Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 8
作者:
Fang, Feifei
;
Hu, Shulei
;
Li, Chunpu
;
Wang, Qian
;
Wang, Run
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
[n+1] annulation
C(sp(3))-H bond activation
N-N bond activation
pyrazolidinones
spiropyrazolones
Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex
期刊论文
NEUROPHARMACOLOGY, 2021, 卷号: 194, 页码: 10
作者:
Zhang, Bing
;
Yang, Xili
;
Ye, Luyu
;
Liu, Rui
;
Ye, Binglu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/08/17
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