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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
发表日期
2020 [11]
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发表日期:2020
专题:上海药物研究所
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Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408
作者:
Liu, Jian-Guo
;
Zhao, Danfeng
;
Gong, Qi
;
Bao, Fengxia
;
Chen, Wen-Wen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase-3
bisindole-substituted aminopyrazoles
Alzheimer's disease
oxidative neurotoxicity
microglial inflammation
An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy
期刊论文
NATURE BIOMEDICAL ENGINEERING, 2020, 页码: 16
作者:
Wang, Cong
;
Sun, Wanbing
;
Zhang, Jun
;
Zhang, Jianping
;
Guo, Qinghua
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/12/21
Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy
期刊论文
CELL DEATH AND DIFFERENTIATION, 2020, 页码: 17
作者:
Guo, Huijie
;
Pu, Mei
;
Tai, Yusi
;
Chen, Yuxiang
;
Lu, Henglei
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2020/12/24
Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 256, 页码: 8
作者:
Zhang, Meng-Qi
;
Ren, Xia
;
Zhao, Qing
;
Yue, Shi-Jun
;
Fu, Xiu-Mei
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Acanthus ilicifolius L.
Total phenylethanoid glycosides
Hepatoprotective
Antioxidant
The axial chirality hidden in vitamin D and its application in cocrystal prediction
期刊论文
CRYSTENGCOMM, 2020, 卷号: 22, 期号: 18, 页码: 3095-3099
作者:
Guo, Mengfei
;
Zhang, Zaiyong
;
Chen, Zhaoqiang
;
Ding, Qiaoce
;
Lu, Liye
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery
期刊论文
CHEMICAL SCIENCE, 2020, 卷号: 11, 期号: 17, 页码: 4397-4402
作者:
Duan, Wenjia
;
Yue, Qi
;
Liu, Ying
;
Zhang, Yunfei
;
Guo, Qinghua
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2020/07/01
Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone
期刊论文
CRYSTAL GROWTH & DESIGN, 2020, 卷号: 20, 期号: 5, 页码: 3053-3063
作者:
Guo, Chunyang
;
Zhang, Qi
;
Zhu, Bingqing
;
Zhang, Zaiyong
;
Ma, Xiaoyu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies
期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 7, 页码: 3626-3635
作者:
Shi, Cheng-Cheng
;
Chen, Tian-Ran
;
Zhang, Qi-Hua
;
Wei, Ling-Hua
;
Huang, Chao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection
期刊论文
ANALYTICAL CHEMISTRY, 2020, 卷号: 92, 期号: 1, 页码: 699-706
作者:
Dong, Ying
;
Li, Xiao-Rong
;
Chen, Qi
;
Guo, Rui-Ying
;
Tang, Bi-Xi
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
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