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浏览/检索结果: 共24条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan 收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy 期刊论文 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 162, 页码: 107-115 作者:  Bian, Youcheng;  Zeng, Hui;  Tao, Hong;  Huang, Lulin;  Du, Zhenyun 收藏  |  浏览/下载：14/0  |  提交时间：2020/12/24 Polygala tenuifolia  Pectin  Pancreatic cancer  Apoptosis  Autophagy   A phase II randomized trial of sodium oligomannate in Alzheimer's dementia 期刊论文 ALZHEIMERS RESEARCH & THERAPY, 2020, 卷号: 12, 期号: 1, 页码: 10 作者:  Wang, Tao;  Kuang, Weihong;  Chen, Wei;  Xu, Wenwei;  Zhang, Liming 收藏  |  浏览/下载：63/0  |  提交时间：2020/12/21 Sodium oligomannate  Efficacy  Safety  Alzheimer's disease  Clinical trial   A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia 期刊论文 Alzheimer's Research & Therapy, 2020, 卷号: 12, 期号: 1 作者:  Wang,Tao;  Kuang,Weihong;  Chen,Wei;  Xu,Wenwei;  Zhang,Liming 收藏  |  浏览/下载：70/0  |  提交时间：2020/12/24 Sodium oligomannate  Efficacy  Safety  Alzheimer’s disease  Clinical trial   Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12 作者:  Pan, Lu-lu;  Yang, Yong;  Hui, Min;  Wang, Shuo;  Li, Cui-yun 收藏  |  浏览/下载：82/0  |  提交时间：2020/12/24 forsythin  pharmacokinetics  drug metabolism  drug excretion  sulfation  glucuronidation  organic anion transporter 3   Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737 作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao 收藏  |  浏览/下载：28/0  |  提交时间：2020/12/21 Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737 作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao 收藏  |  浏览/下载：23/0  |  提交时间：2020/12/21 Optimizing chemical reaction conditions using deep learning: a case study for the Suzuki-Miyaura cross-coupling reaction 期刊论文 ORGANIC CHEMISTRY FRONTIERS, 2020, 卷号: 7, 期号: 16, 页码: 2269-2277 作者:  Fu, Zunyun;  Li, Xutong;  Wang, Zhaohui;  Li, Zhaojun;  Liu, Xiaohong 收藏  |  浏览/下载：33/0  |  提交时间：2020/12/24 Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway 期刊论文 FOOD & FUNCTION, 2020, 卷号: 11, 期号: 8, 页码: 6961-6970 作者:  Tao, Hong;  Chen, Xia;  Du, Zhenyun;  Ding, Kan 收藏  |  浏览/下载：21/0  |  提交时间：2020/12/24 Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11 作者:  Chen, Yu;  Bi, Xiaoyang;  Zhang, Fengcai;  Sun, Zhongya;  Xu, Pan 收藏  |  浏览/下载：24/0  |  提交时间：2020/12/24 In silico screening  Drug design  CBP  Bromodomain  Inhibitor  Acute Myeloblastic Leukemia