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科研机构
上海药物研究所 [25]
内容类型
期刊论文 [25]
发表日期
2020 [25]
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发表日期:2020
专题:上海药物研究所
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Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells
期刊论文
CELL REPORTS, 2020, 卷号: 33, 期号: 10, 页码: 24
作者:
Feng, Sisi
;
Wu, Jiaying
;
Qiu, Wei-Lin
;
Yang, Li
;
Deng, Xiaogang
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 71, 页码: 43299-43311
作者:
Hu, Min-Qi
;
Li, Heng
;
Lin, Ying
;
Zhang, Ying
;
Tang, Jie
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/05/24
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
The novel small-molecule TPN10456 inhibits Th17 cell differentiation and protects against experimental autoimmune encephalomyelitis
期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 页码: 4
作者:
Yang, Cuixia
;
Lv, Jie
;
Jiang, Xiangrui
;
Xiang, Zhenglong
;
Gong, Ran
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 19, 页码: 10972-10983
作者:
Ma, Yuqin
;
Luo, Qichao
;
Fu, Jie
;
Che, Yanxin
;
Guo, Fei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/05/24
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein
期刊论文
ONCOGENE, 2020, 页码: 14
作者:
Qian, Wenli
;
Li, Qi
;
Wu, Xinglong
;
Li, Wenguo
;
Li, Qiwei
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/12/21
Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy
期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 10
作者:
Duan, Jia
;
Shen, Dan-dan
;
Zhou, X. Edward
;
Bi, Peng
;
Liu, Qiu-feng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 16, 页码: 6
作者:
Su, Zhicheng
;
Yang, Tingyuan
;
Wang, Jie
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
EGFR
NSCLC
C797S
Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 9
作者:
Liu, Wenpei
;
Song, Ziteng
;
Wang, Huimei
;
Yang, Xueyuan
;
Joubert, Elizabeth
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2020/12/24
Nitric oxide inhibitory effects
Ajuga pantantha
Diterpenoids
Inflammation
Molecular docking
Zebrafish model
Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 198, 页码: 11
作者:
Wang, Zhi-Cheng
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/12/24
Capsaicin
Nitrothiophene
Multidrug-resistant S. aureus
Antibacterial agent
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