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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan 收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19 作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue 收藏  |  浏览/下载：22/0  |  提交时间：2020/12/21 Metabolic pathways  Isocitrate dehydrogenase 2  Conformational restriction  Macrocyclic derivatives  Inhibitors   Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19 作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue 收藏  |  浏览/下载：23/0  |  提交时间：2020/12/21 Metabolic pathways  Isocitrate dehydrogenase 2  Conformational restriction  Macrocyclic derivatives  Inhibitors   Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11 作者:  Chen, Yu;  Bi, Xiaoyang;  Zhang, Fengcai;  Sun, Zhongya;  Xu, Pan 收藏  |  浏览/下载：24/0  |  提交时间：2020/12/24 In silico screening  Drug design  CBP  Bromodomain  Inhibitor  Acute Myeloblastic Leukemia   New Steroids from the South China Sea Soft Coral Lobophytum sp. 期刊论文 CHEMISTRY & BIODIVERSITY, 2020, 页码: 6 作者:  Ye, Fei;  Zhou, Yu-Bo;  Li, Jia;  Gu, Yu-Cheng;  Guo, Yue-Wei 收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01 soft coral  Lobophytum  steroids  biological activity  NF-kappa B   Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion 期刊论文 ADVANCED SCIENCE, 2020, 页码: 13 作者:  Sun, Zhongya;  Zhang, Hao;  Zhang, Yuanyuan;  Liao, Liping;  Zhou, Wen 收藏  |  浏览/下载：107/0  |  提交时间：2020/07/01 anti-metastasis activities  crystal structures  inhibitors  novel pockets  rho family proteins   Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 卷号: 59, 期号: 6, 页码: 2429-2439 作者:  Gao, Cheng-Long;  Hou, Gui-Ge;  Liu, Jin;  Ru, Tong;  Xu, Ya-Zhou 收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 anti-inflammatory  drug discovery  heterocycles  photoaffinity labeling  proteins   Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 2, 页码: 15 作者:  Liu, Lingjun;  Li, Jiyuan;  Dai, Wenhao;  Gao, Feng;  Chen, Kaixian 收藏  |  浏览/下载：43/0  |  提交时间：2020/07/01 Rhodium(III)  redox-neutral  [3+3] annulation  N-nitrosoaniline  cyclopropenones  quinolin-4(1H)-ones   Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 1, 页码: 13 作者:  Lin, Ying;  Xing, Dong;  Wu, Wen-Biao;  Xu, Gao-Ya;  Yu, Li-Fang 收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 benzofuro[3,2-c]quinolines  3-(2-methoxyphenyl)quinolin-4(1H)one  MV-4-11 cell line  antileukemia activity