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浏览/检索结果: 共184条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070 作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui 收藏  |  浏览/下载：92/0  |  提交时间：2020/07/01 Common activation mechanism of class A GPCRs 期刊论文 ELIFE, 2019, 卷号: 8, 页码: 31 作者:  Zhou, Qingtong;  Yang, Dehua;  Wu, Meng;  Guo, Yu;  Guo, Wangjing 收藏  |  浏览/下载：66/0  |  提交时间：2020/07/01 Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15 作者:  Lu, Wenchao;  Wang, Jun;  Li, Yong;  Tao, Hongru;  Xiong, Huan 收藏  |  浏览/下载：94/0  |  提交时间：2020/07/01 Hippo pathway  TEAD transcription factor  Covalent inhibitor  Palmitoylation inhibitor   A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer 期刊论文 CELL METABOLISM, 2019, 卷号: 30, 期号: 6, 页码: 1107-+ 作者:  Huang, Ke;  Liang, Qian;  Zhou, Ye;  Jiang, Lu-lu;  Gu, Wei-ming 收藏  |  浏览/下载：77/0  |  提交时间：2020/07/01 Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease 期刊论文 PHARMACOLOGICAL RESEARCH, 2019, 卷号: 150, 页码: 14 作者:  Zhang, Yu;  Wu, Qimei;  Zhang, Lei;  Wang, Qing;  Yang, Zexian 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 Caffeic acid  A53T  Parkinson's disease  Autophagy  JNK   Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer 期刊论文 PHYTOMEDICINE, 2019, 卷号: 65, 页码: 11 作者:  Wang Yuwei;  Tang Chunping;  Yao Sheng;  Lai Huanling;  Li Runze 收藏  |  浏览/下载：38/0  |  提交时间：2020/07/01 Non-small cell lung cancer  Natural product  Croton tiglium  Protein kinase C  Molecular modelling   Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun 收藏  |  浏览/下载：75/0  |  提交时间：2020/07/01 PI3K alpha inhibitors  proliferation inhibition  thieno[3  2-d]pyrimidine derivatives   3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586 作者:  Shan, Hui;  Yao, Sheng;  Ye, Yang;  Yu, Qiang 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 JAK/STAT  3-deoxy-2 beta,16-dihydroxynagilactone E  tyrosine kinase inhibitor  allosteric inhibitor  cancer   Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs 期刊论文 MOLECULES, 2019, 卷号: 24, 期号: 23, 页码: 13 作者:  Shao, Pingxuan;  Zhou, Yan;  Yang, Dehua;  Wang, Ming-Wei;  Lu, Wei 收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01 pentafluorosulfanyl  aryl propionamide  androgen receptor  agonist  SARMs   HRAS(G12s) mutant mediates resistance to a PI3K alpha inhibitor CYH33 in esophageal squamous cell carcinomas 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2019, 卷号: 18, 期号: 12, 页码: 2 作者:  Wang, Yuxiang;  Zhang, Xu;  Ma, Qingyang;  Zhang, Xi;  Yang, Chunhao 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01