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浏览/检索结果: 共5条，第1-5条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 339-350 作者:  Tian, Ye;  Liu, Zhaoqiang;  Liu, Jinghan;  Huang, Boshi;  Kang, Dongwei 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 HIV-1  NNRTIs  Triazole  Diarylnicotinamide  Entrance channel  Drug  design   First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 8, 页码: 1348-1351 作者:  Huang, Boshi;  Liu, Xinhao;  Tian, Ye;  Kang, Dongwei;  Zhou, Zhongxia 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11 HIV-1 NNRTI  RDEA427  Carbonate prodrug  Anti-HIV activity  Metabolic  stability   Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel" 期刊论文 ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 卷号: 16, 期号: 6, 页码: 1014-1028 作者:  Zhou, Zhongxia;  Liu, Tao;  Kang, Dongwei;  Huo, Zhipeng;  Wu, Gaochan 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155, 页码: 714-724 作者:  Sun, Lin;  Gao, Ping;  Dong, Guanyu;  Zhang, Xujie;  Cheng, Xiqiang 收藏  |  浏览/下载：10/0  |  提交时间：2019/12/11 HAART  HIV-1 dual inhibitors  HIV-1 IN  RNase H  5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives  Privileged  structure   The discovery of novel diarylpyri(mi) dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2051-2060 作者:  Lu, Xueyi;  Yang, Jiapei;  Kang, Dongwei;  Gao, Ping;  Daelemans, Dirk 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 HIV-1  HIV-2  NNRTIs  DAPY  Drug design  Entrance channel