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浏览/检索结果: 共4条，第1-4条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents 期刊论文 ACS chemical neuroscience, 2018 作者:  Xu, Yixiang;  Zhang, Jian;  Wang, Huan;  Mao, Fei;  Bao, Keting 收藏  |  浏览/下载：84/0  |  提交时间：2019/01/08 Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125 作者:  Liu, Wenwen;  Wang, Huan;  Li, Xiaokang;  Xu, Yixiang;  Zhang, Jian 收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Depression  Cognitive impairment  Multitarget-directed ligand  5-HT1A agonist  5-HT reuptake inhibition  ChE inhibition   Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5) 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636 作者:  Ni, Wei;  Wang, Huan;  Li, Xiaokang;  Zheng, Xinyu;  Wang, Manjiong 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 Multifunctional agents  AChE inhibitors  PDE5 inhibitors  Alzheimer's disease   Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345 作者:  Mao, Fei;  Wang, Huan;  Ni, Wei;  Zheng, Xinyu;  Wang, Manjiong 收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08 Alzheimer's disease  drug repositioning  dual-target inhibitor  AChE inhibition  PDE5 inhibition