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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 发表日期：2016     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile 期刊论文 CURRENT PHARMACEUTICAL DESIGN, 2016, 卷号: 22, 期号: 46 作者:  Mao, Tian-Qi;  He, Qiu-Qin;  Chen, Wen-Xue;  Tang, Gang-Feng;  Chen, Fen-Er 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/05 Diarylpyrimidine  quinolone  hybrids  HIV-1 reverse transcriptase  anti-HIV  K103N/Y181C   Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 121, 页码: 352-363 作者:  Chen, Wenmin;  Zhan, Peng;  Daelemans, Dirk;  Yang, Jiapei;  Huang, Boshi 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/16 Piperidyl  Morpholinyl  Pyridine  Diarylpyrimidines  NNRTI  HIV   Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 3, 页码: 380-385 作者:  Li, Wenxin;  Huang, Boshi;  Kang, Dongwei;  De Clercq, Erik;  Daelemans, Dirk 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/16 anti-HIV-1 activity  drug design  HIV-1  NNRTIs  S-DABOs   Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 87, 期号: 2, 页码: 283-289 作者:  Huang, Boshi;  Li, Xiao;  Zhan, Peng;  De Clercq, Erik;  Daelemans, Dirk 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/17 anti-HIV activity  bioisosterism  HIV-1 RT  molecular hybridization  non-nucleoside reverse transcriptase inhibitors   Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 18, 页码: 4424-4433 作者:  Lu, Xueyi;  Li, Xiao;  Yang, Jiapei;  Huang, Boshi;  Kang, Dongwei 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17 HIV-1  AIDS  NNRTIs  Purinylthioacetanilide  Anti-HIV activity  Drug  design  Bioisosterism   Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 2, 页码: 241-253 作者:  Li, Xiao;  Huang, Boshi;  Zhou, Zhongxia;  Gao, Ping;  Pannecouque, Christophe 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17 antiviral activity  drug design  HIV  imidazo[4,5-b]pyridin-2-ylthioacetanilides  molecular modeling  NNRTIs  SAR   Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 115, 页码: 53-62 作者:  Meng, Qing;  Chen, Xuwang;  Kang, Dongwei;  Huang, Boshi;  Li, Wenxin 收藏  |  浏览/下载：10/0  |  提交时间：2019/12/17 HIV-1 NNRTIs  DAPY derivatives  Dual structural conformations  Entrance  channel  SARs