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浏览/检索结果: 共20条，第1-10条 帮助 限定条件 发表日期：2016    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata 期刊论文 TETRAHEDRON LETTERS, 2016, 卷号: 57, 期号: 49, 页码: 5475-5478 作者:  Lei, Chun;  Zhang, Lai-Bin;  Yang, Jing;  Gao, Li-Xin;  Li, Jing-Ya 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Macaranga denticulate  Euphorbiaceae  Dimeric chalcone  Macdentichalcone  Protein tyrosine phosphatase 1B   Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 12, 页码: 1587-1596 作者:  Wang, Yue-qin;  Shen, Ai-jun;  Sun, Jing-ya;  Wang, Xin;  Liu, Hong-chun 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 non-small cell lung cancer  gefitinib resistance  Hsp90   Discovery of 4-chloro-3-(5-(pyridin-3-yl)-1,2,4-oxadiazole-3-yl) benzamides as novel RET kinase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 23, 页码: 5679-5684 作者:  Han, Mei;  Li, Shan;  Ai, Jing;  Sheng, Rong;  Hu, Yongzhou 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 RET kinase inhibitor  1,2,4-Oxadiazole  Anti-cancer therapy   Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 22, 页码: 5399-5402 作者:  Han, Mei;  Wang, Chengyan;  Ji, Yinchun;  Song, Zilan;  Xing, Li 收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08 EML4-ALK kinase  Oxidative metabolism  Benzo[b]carbazolone  hERG  Antitumor activity   kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice 期刊论文 NEUROPHARMACOLOGY, 2016, 卷号: 110, 页码: 92-101 作者:  Wang, Yu-Jun;  Hang, Ai;  Lu, Yu-Chen;  Long, Yu;  Zan, Gui-Ying 收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 kappa Opioid receptor  pERK1/2  Region-specific  Dual effects  Anxiety   Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors 期刊论文 MOLECULES, 2016, 卷号: 21, 期号: 10 作者:  Zhang, Zhen;  Zhao, Dongmei;  Dai, Yang;  Cheng, Maosheng;  Geng, Meiyu 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 cancer  FGFR  inhibitor  4-substituted-1H-indazole   The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor beta 1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-beta 1 and Suppresses Tumor Metastasis 期刊论文 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2016, 卷号: 359, 期号: 1, 页码: 54-61 作者:  Zhou, Ji;  You, Wenjie;  Sun, Guangqiang;  Li, Yixuan;  Chen, Bi 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 An orally available tyrosine kinase ALK and RET dual inhibitor bearing the tetracyclic benzo[b]carbazolone core 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 118, 页码: 244-249 作者:  Song, Zilan;  Xia, Zongjun;  Ji, Yinchun;  Xing, Li;  Gao, Yinglei 收藏  |  浏览/下载：70/0  |  提交时间：2019/01/08 Benzo[b]carbazolones  ALK inhibitors  RET kinase  Antiresistance  Non-small-cell lung cancer  Preclinical study   Discovery of 3-(5 '-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 14, 页码: 6690-6708 作者:  Yan, Wei;  Wang, Xinyi;  Dai, Yang;  Zhao, Bin;  Yang, Xinying 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b] [1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 116, 页码: 239-251 作者:  Zhan, Zhengsheng;  Peng, Xia;  Liu, Qiufeng;  Chen, Fang;  Ji, Yinchun 收藏  |  浏览/下载：49/0  |  提交时间：2019/01/08 Antitumor  c-Met  Kinase inhibitor  Triazolotriazines