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科研机构
合肥物质科学研究院 [21]
内容类型
期刊论文 [21]
发表日期
2022 [6]
2021 [7]
2020 [1]
2019 [1]
2018 [3]
2017 [3]
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专题:合肥物质科学研究院
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Duplex real-time fluorescent recombinase polymerase amplification for the rapid and sensitive detection of two resistance genes in drug-resistant Staphylococcus aureus
期刊论文
JOURNAL OF MICROBIOLOGICAL METHODS, 2022, 卷号: 202
作者:
Shi, Zhonglin
;
Li, Yanan
;
Hu, Anzhong
;
Cui, Junsheng
;
Shao, Min
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/12/23
Drug -resistant Staphylococcus aureus
ermA
mecA
Recombinase polymerase amplification
Resistance genes
S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71
作者:
Li, Haobin
;
Cai, Maohua
;
Cao, Fei
;
Yu, Dehua
;
Yang, Jing
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/12/22
STAT3 inhibitor
Quinone derivative
S3I-201
Anti -gastric cancer drug
Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
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  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists
期刊论文
PHARMACEUTICALS, 2022, 卷号: 15
作者:
Sun, Lei
;
Zheng, Zhi-Ming
;
Shao, Chang-Sheng
;
Zhang, Zhi-Yong
;
Li, Ming-Wei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/12/22
glucagon-like peptide-1
GLP-1 receptor agonist
functional protein design
molecular dynamics simulation
long-acting antihyperglycemic
Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:
Qu, Bingxue
;
Xu, Yongjin
;
Lu, Yang
;
Zhuang, Weihao
;
Jin, Xinxin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/12/23
XPO1
Multiple myeloma
MM.1S
N-phenylsulfonamide
Oral administration
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
期刊论文
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2022, 卷号: 22
作者:
Xu, Yipeng
;
Pachnikova, Gabriela
;
Wang, He
;
Wu, Yaoyao
;
Przybilla, Dorothea
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2022/12/23
IC50
docetaxel
spheroids
drug testing
preclinical models
prostate cancer
2D clinical models
3D clinical models
cell culture
An overview of kinase downregulators and recent advances in discovery approaches
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Wang, Beilei
;
Wu, Hong
;
Hu, Chen
;
Wang, Haizhen
;
Liu, Jing
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/25
Protein degradation technology: a strategic paradigm shift in drug discovery
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14
作者:
Li, Haobin
;
Dong, Jinyun
;
Cai, Maohua
;
Xu, Zhiyuan
;
Cheng, Xiang-Dong
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/11/01
Protein degradation
Degradation pathway
Degradation technology
PROTAC
Monomeric degraders
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Dong, Jinyun
;
Cheng, Xiang-Dong
;
Zhang, Wei-Dong
;
Qin, Jiang-Jiang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/08/31
Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy
期刊论文
ADVANCED HEALTHCARE MATERIALS, 2021
作者:
Zhao, Di
;
Jiang, Kai
;
Wang, Yuqi
;
Cheng, Jin
;
Mo, Fangli
收藏
  |  
浏览/下载:122/0
  |  
提交时间:2021/03/15
controllable esterase response
high loading efficiency
lung targeting
multi-drug resistance
universal drug encapsulation
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