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科研机构
山东大学 [40]
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期刊论文 [39]
会议论文 [1]
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2019 [6]
2018 [10]
2017 [5]
2016 [3]
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专题:山东大学
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Discovery of Novel Bromophenol Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3051-3067
作者:
Guo, Chuanlong
;
Wang, Lijun
;
Li, Xinxue
;
Wang, Shuaiyu
;
Yu, Xuemin
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/11
Novel C7-substituted coumarins as selective monoamine oxidase inhibitors: Discovery, synthesis and theoretical simulation
期刊论文
Molecules, 2019, 卷号: 24, 期号: 21
作者:
Wang D.
;
Hong R.-Y.
;
Guo M.
;
Liu Y.
;
Chen N.
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
BRS-3D
In silico pharmacokinetic predictions
Molecular dynamic simulations
Monoamine oxidase (MAO) inhibitors
Subtype selectivity
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: 183
作者:
Jing L.
;
Wu G.
;
Hao X.
;
Olotu F.A.
;
Kang D.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
Anticancer agents
Cdc25 inhibitors
Click chemistry
Subtype selectivity
Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors
期刊论文
DRUG DISCOVERY TODAY, 2019, 卷号: 24, 期号: 2, 页码: 629-635
作者:
Jing, Lanlan
;
Wu, Gaochan
;
Kang, Dongwei
;
Zhou, Zhongxia
;
Song, Yuning
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/11
Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 8, 页码: 1122-1127
作者:
Liang, Tao
;
Hou, Xuben
;
Zhou, Yi
;
Yang, Xinying
;
Fang, Hao
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
HDAC6
isoform-selective
2,4-imidazolinedione
antiproliferative
apoptosis
Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 735-751
作者:
Jin, Xin
;
Merrett, James
;
Tong, Sheng
;
Flower, Bartholomew
;
Xie, Jianling
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Mnk
eIF4E inhibition
Thieno[2,3-d]pyrimidine
Selective inhibitor
Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 页码: 30-38
作者:
Zheng, Hongbo
;
Li, Lin
;
Sun, Bin
;
Gao, Yun
;
Song, Wei
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  |  
浏览/下载:113/0
  |  
提交时间:2019/12/11
PDE5 inhibitors
Pyrroloquinolones
Bioavailability
Male erectile
dysfunction (MED)
Recent advances in the discovery of potent and selective HDAC6 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 1406-1418
作者:
Wang, Xiu-Xiu
;
Wan, Ren-Zhong
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
HDAC6
HDAC6 inhibitors
Zinc binding groups
Hydroxamic acids
Sulfur
containing ZBGs
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors
期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 151, 页码: 9-17
作者:
Ma C.-C.
;
Zhang C.-M.
;
Tang L.-Q.
;
Liu Z.-P.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
B-Cell inhibition
PI3K isoform selectivity
PI3Kδ inhibitor
PI3Kδ/γ inhibitors
Quinazolinones
Evaluation of WO2017018805: 1,3,4-oxadiazole sulfamide derivatives as selective HDAC6 inhibitors
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2018, 卷号: 28, 期号: 8, 页码: 647-651
作者:
Liang, Yuan-Yuan
;
Zhang, Cheng-Mei
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
HDAC6
inhibitors
134-oxadiazole
sulfamide
zinc-binding group
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