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科研机构
上海药物研究所 [187]
内容类型
期刊论文 [185]
会议论文 [2]
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2021 [17]
2020 [18]
2019 [17]
2018 [32]
2017 [21]
2016 [19]
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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
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  |  
浏览/下载:17/0
  |  
提交时间:2021/12/16
Recombinant cancer nanovaccine for targeting tumor-associated macrophage and remodeling tumor microenvironment
期刊论文
NANO TODAY, 2021, 卷号: 40, 页码: 14
作者:
Tang, Yisi
;
Fan, Wufa
;
Chen, Guihua
;
Zhang, Meng
;
Tang, Xueping
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/12/01
Cancer therapeutic vaccine
Legumain
Tumor-associated macrophage
Trichosanthin
Liposome
Adjuvant
Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 11219-11228
作者:
Zheng, Mengmeng
;
Li, Chunpu
;
Zhou, Mi
;
Jia, Ru
;
Cai, Gang
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9217-9237
作者:
Liang, Xuewu
;
Sun, Chenxia
;
Li, Chunpu
;
Yu, Haolan
;
Wei, Xiaohui
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/17
A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
期刊论文
Cancer Cell International, 2021, 卷号: 21, 期号: 1
作者:
Gao,Xuejie
;
Li,Bo
;
Ye,Anqi
;
Wang,Houcai
;
Xie,Yongsheng
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2021/06/11
Multiple myeloma
Anti-tumor activity
NF-κB
A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-kappa B pathway
期刊论文
CANCER CELL INTERNATIONAL, 2021, 卷号: 21, 期号: 1, 页码: 10
作者:
Gao, Xuejie
;
Li, Bo
;
Ye, Anqi
;
Wang, Houcai
;
Xie, Yongsheng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Multiple myeloma
Anti-tumor activity
NF-kappa B
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