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科研机构
上海药物研究所 [123]
内容类型
期刊论文 [121]
会议论文 [1]
学位论文 [1]
发表日期
2021 [11]
2020 [7]
2019 [9]
2018 [5]
2017 [6]
2016 [14]
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Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/12/16
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:
Huang, Huoming
;
Li, Xueping
;
Xie, Peng
;
Li, Xinwei
;
Xu, XueJun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/08/17
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9217-9237
作者:
Liang, Xuewu
;
Sun, Chenxia
;
Li, Chunpu
;
Yu, Haolan
;
Wei, Xiaohui
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/17
Identification of novel anti-inflammatory Nur77 modulators by virtual screening
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 7
作者:
Ding, Xiaoyu
;
Zhao, Zijie
;
Wu, Yue
;
Zhang, Hao
;
Chen, Kaixian
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
Nur77
Binding site evaluation
Virtual Screening
Inflammation
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 6
作者:
Xiong, Fengmin
;
Ding, Xiaoyu
;
Zhang, Hao
;
Luo, Xiaomin
;
Chen, Kaixian
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
Monoacylglycerol lipase
Inhibitor
Virtual screening
Inflammation
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
期刊论文
MOLECULAR MEDICINE REPORTS, 2021, 卷号: 23, 期号: 5, 页码: 12
作者:
Huang, He-Ming
;
Zhou, Xiao-Ru
;
Liu, Yan-Jun
;
Fan, Shi-Jie
;
Liao, Li-Ping
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
liver fibrosis
hepatic stellate cell
histone deacetylase inhibitor
epigenetics
givinostat
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus L. f. Ker-Gawl. as a case study
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 卷号: 44, 期号: 7, 页码: 1440-1451
作者:
Jin, Xu
;
Zhang, Jianqing
;
Li, Yun
;
Wu, Wenyong
;
Zhang, Hang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/05/24
authentication
multicriteria decision making
nontargeted metabolomics
quality markers
traditional Chinese medicine
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker-Gawl. as a case study
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 12
作者:
Jin, Xu
;
Zhang, Jianqing
;
Li, Yun
;
Wu, Wenyong
;
Zhang, Hang
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/05/24
authentication
multicriteria decision making
nontargeted metabolomics
quality markers
traditional Chinese medicine
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