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科研机构
上海药物研究所 [10]
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期刊论文 [10]
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2021 [1]
2020 [3]
2019 [1]
2015 [1]
2012 [3]
2009 [1]
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Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Yu, Yan-yan
;
Cui, Shi-chao
;
Zheng, Tian-nan
;
Ma, Hai-jian
;
Xie, Zhi-fu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
insulin resistance
sarsasapogenin
adipose tissue inflammation
macrophage-adipocyte crosstalk
IKK/NF-kappa B
JNK
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
期刊论文
CELL METABOLISM, 2019, 卷号: 30, 期号: 6, 页码: 1107-+
作者:
Huang, Ke
;
Liang, Qian
;
Zhou, Ye
;
Jiang, Lu-lu
;
Gu, Wei-ming
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2020/07/01
2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 4, 页码: 483-496
作者:
Zhang, Jin
;
Zhang, Li-na
;
Chen, Dong-mei
;
Fu, Yan-yun
;
Zhang, Feng
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid
lipogenesis
SREBP-1c
AMPK
mTOR
hepatic lipid accumulation
obesity
metabolic disorders
Strategies for Improving the Quantitative Bioanalytical Performance of LC-MS in Pharmacokinetic Studies
期刊论文
CURRENT DRUG METABOLISM, 2012, 卷号: 13, 期号: 9, 页码: 1206-1212
作者:
Li, Li
;
Tian, Dandan
;
Chen, Feng
;
Yang, Junling
;
Yu, Ke
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Pharmacokinetics
LC-MS
matrix effects
sensitivity enhancement
LC-electrolyte effects
pulse gradient chromatography
Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice
期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: 7
作者:
Zeng, Xiao-Yi
;
Wang, Yi-Ping
;
Cantley, James
;
Iseli, Tristan J.
;
Molero, Juan Carlos
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice
期刊论文
DIABETOLOGIA, 2012, 卷号: 55, 期号: 5, 页码: 1469-1481
作者:
Huang, S. -L.
;
Yu, R. -T.
;
Gong, J.
;
Feng, Y.
;
Dai, Y. -L.
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
AMP-activated protein kinase
Gluconeogenesis
Glucose uptake
Lipid synthesis
Mitochondria
Natural compound
Respiratory complex I
AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 卷号: 284, 期号: 10, 页码: 6175-6184
作者:
Zang, Yi
;
Yu, Li-Fang
;
Nan, Fa-Jun
;
Feng, Lin-Yin
;
Li, Jia
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
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