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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
发表日期
2021 [3]
2020 [2]
2019 [2]
2018 [2]
2017 [2]
2016 [1]
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专题:上海药物研究所
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:
Wang, Congcong
;
Zhang, Yu-Fang
;
Guo, Shimeng
;
Zhao, Quan
;
Zeng, Yanping
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis
期刊论文
THERANOSTICS, 2021, 卷号: 11, 期号: 20, 页码: 9821-9832
作者:
Li, Xiaoxun
;
Liang, Yajun
;
Lian, Cheng
;
Peng, Fangli
;
Xiao, Yansen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/04
Breast cancer
Bone metastasis
Osteoclastogenesis
CST6
Peptide drug
Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2020, 卷号: 321, 页码: 483-496
作者:
Sun, Tao
;
Zhang, Guangping
;
Guo, Zhongyuan
;
Chen, Qinjun
;
Zhang, Yujie
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Cu chelator
Antiangiogenesis
Theranostic
Real-time reporting
Co-delivery
Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 卷号: 59, 期号: 6, 页码: 2429-2439
作者:
Gao, Cheng-Long
;
Hou, Gui-Ge
;
Liu, Jin
;
Ru, Tong
;
Xu, Ya-Zhou
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
anti-inflammatory
drug discovery
heterocycles
photoaffinity labeling
proteins
TRAIL-based gene delivery and therapeutic strategies
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1373-1385
作者:
Zhong, Hui-hai
;
Wang, Hui-yuan
;
Li, Jian
;
Huang, Yong-zhuo
收藏
  |  
浏览/下载:115/0
  |  
提交时间:2020/07/01
TRAIL
gene delivery
gene therapy
DNA
drug delivery systems
non-viral vectors
cancer therapy
trailbasedgenedeliveryandtherapeuticstrategies
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1373
作者:
Zhong Huihai
;
Wang Huiyuan
;
Li Jian
;
Huang Yongzhuo
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
APOPTOSIS-INDUCING LIGAND
MESENCHYMAL STEM-CELLS
PROSTATE-CANCER CELLS
DEATH RECEPTOR 5
CO-DELIVERY
IN-VIVO
MEDIATED APOPTOSIS
ANTITUMOR-ACTIVITY
TUMORICIDAL ACTIVITY
PROTEIN EXPRESSION
TRAIL
gene delivery
gene therapy
DNA
drug delivery systems
non-viral vectors
cancer therapy
Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 24, 页码: 11298-11308
作者:
Liu, Jin
;
Li, Heng
;
Chen, Kai-Xian
;
Zuo, Jian-Ping
;
Guo, Yue-Wei
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes
期刊论文
BRAIN, 2018, 卷号: 141, 页码: 1782-1798
作者:
Song, Haikun
;
Li, Hexuan
;
Guo, Shimeng
;
Pan, Yuyin
;
Fu, Yuhua
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
GPCR
target validation
polyQ
neurodegeneration
antagonists
First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans
期刊论文
ARCHIVES OF TOXICOLOGY, 2017, 卷号: 91, 期号: 12, 页码: 3913-3925
作者:
Yang, Mengbi
;
Ruan, Jianqing
;
Gao, Hong
;
Li, Na
;
Ma, Jiang
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Pyrrolizidine alkaloid N-oxide
Pyrrolizidine alkaloid
Hepatic sinusoidal obstruction syndrome
Pyrrole-protein adduct
Biotransformation
Toxicokinetic
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