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科研机构
上海药物研究所 [24]
内容类型
期刊论文 [24]
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2021 [4]
2020 [3]
2019 [3]
2018 [3]
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2014 [3]
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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
期刊论文
ISCIENCE, 2021, 卷号: 24, 期号: 11, 页码: 22
作者:
Hu, Lin
;
Chen, Fuxian
;
Wu, Chao
;
Wang, Jun
;
Chen, Si-si
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/18
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
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  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
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  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 7, 页码: 3956-3975
作者:
Zhang, Hefeng
;
Peng, Xia
;
Dai, Yang
;
Shao, Jingwei
;
Ji, Yinchun
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  |  
浏览/下载:16/0
  |  
提交时间:2021/06/11
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Dai, Meng-di
;
Wang, Yue-liang
;
Fan, Jun
;
Dai, Yang
;
Ji, Yin-chun
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  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
receptor tyrosine kinase
FGFR inhibitor
DW14383
antitumor activity
SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7
作者:
Xia, Zong-jun
;
Ji, Yin-chun
;
Sun, De-qiao
;
Peng, Xia
;
Gao, Ying-lei
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2020/12/21
ROS1 kinase
ROS1 inhibitor
SAF-189s
lorlatinib
crizotinib resistance
G2032R mutant
NSCLC
Proteomic and Phosphoproteomic Maps of Lung Squamous Cell Carcinoma From Chinese Patients
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10, 页码: 13
作者:
Pan, Lulu
;
Wang, Xijun
;
Yang, Longhai
;
Zhao, Lei
;
Zhai, Linhui
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  |  
浏览/下载:17/0
  |  
提交时间:2020/12/24
lung squamous cell carcinoma
proteomics
phosphoproteomics
clustering
lymph node metastasis
cell cycle
Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 171-190
作者:
Liu, Ruiqi
;
Zhang, Zhuqing
;
Yang, Hong
;
Zhou, Kaixin
;
Geng, Meiyu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
p300 inhibitors
Epigenetics
Structure-activity relationship
Sensitive tumor cell proliferation
C646
MiR-183-5p is required for non-small cell lung cancer progression by repressing PTEN
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2019, 卷号: 111, 页码: 1103-1111
作者:
Wang, Huimin
;
Ma, Zhongliang
;
Liu, Xiaomin
;
Zhang, Caiyan
;
Hu, Yanping
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
miR-183-5p
Non-small cell lung cancer
PTEN
Tumorigenesis
Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 1, 页码: 239-244
作者:
Song, Hongshuo
;
Ou, Weidong
;
Feng, Yi
;
Zhang, Junli
;
Li, Fan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
CRF01_AE
Coreceptor tropism
CXCR4
CD4 count
HIV-1 pathogenesis
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