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科研机构
上海药物研究所 [26]
内容类型
期刊论文 [25]
学位论文 [1]
发表日期
2021 [1]
2019 [2]
2018 [4]
2016 [2]
2015 [2]
2014 [2]
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Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 9, 页码: 1069-1073
作者:
Li, Zhongping
;
Ma, Lingling
;
Wu, Chengyong
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
Crystal structure
tubulin
colchicine binding site
inhibitor
MT189
drug design
The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
期刊论文
Molecular cancer therapeutics, 2018, 卷号: 145, 页码: 817-842
作者:
Wang, Xinyi
;
Ai, Jing
;
Liu, Hongyan
;
Peng, Xia
;
Chen, Hui
收藏
  |  
浏览/下载:135/0
  |  
提交时间:2019/01/08
1,4-Diaryl-2-azetidinone
Combretastatin A-4
Tubulin polymerization
Antitumor
Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 6
作者:
Liu, Man
;
Xiao, Chengqian
;
Sun, Mingwei
;
Tan, Minjia
;
Hu, Lihong
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
parthenolide
covalent inhibitor
cell death
JAK/STAT3 signaling
New microtubulin inhibitor MT189 suppresses angiogenesis via the JNK-VEGF/VEGFR2 signaling axis
期刊论文
CANCER LETTERS, 2018, 卷号: 416, 页码: 57-65
作者:
Xu, Lin
;
Wang, Wei
;
Meng, Tao
;
Ma, Lan-Ping
;
Tong, Lin-Jiang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
MT189
Microtubulin inhibitor
VEGF
Src
JNK
Cell adhesion
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 144, 页码: 817-842
作者:
Zhou, Pengfei
;
Liang, Yuru
;
Zhang, Hao
;
Jiang, Hao
;
Feng, Kechang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
1,4-Diaryl-2-azetidinone
Combretastatin A-4
Tubulin polymerization
Antitumor
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 112, 页码: 367-372
作者:
An, Weiteng
;
Wang, Wei
;
Yu, Ting
;
Zhang, Yongliang
;
Miao, Zehong
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Anticancer agents
Tubulin inhibitor
Intra-molecular hydrogen bonding
Colchicine binding site
Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer
期刊论文
ACTA PHARMACEUTICA SINICA B, 2016, 卷号: 6, 期号: 1, 页码: 93-99
作者:
Chen, Danqi
;
Shen, Aijun
;
Fang, Guanghua
;
Liu, Hongchun
;
Zhang, Minmin
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Histone deacetylases inhibitor
Anticancer
Tetrahydroisoquinoline
Structure-activity relationship
Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 95, 页码: 127-135
作者:
Zhang, Xuan
;
Kong, Yannan
;
Zhang, Jie
;
Su, Mingbo
;
Zhou, Yubo
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Colchicine
Dual inhibitor
HDAC
Tubulin
Hybrid
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