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科研机构
上海药物研究所 [30]
内容类型
期刊论文 [30]
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2021 [3]
2020 [1]
2019 [2]
2018 [3]
2016 [5]
2015 [3]
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A simultaneous identification and quantification strategy for determination of sulfhydryl-containing metabolites in normal- and high-fat diet hamsters using stable isotope labeling combined with LC-MS
期刊论文
ANALYTICA CHIMICA ACTA, 2021, 卷号: 1184, 页码: 13
作者:
Chang, Lu
;
Lin, Feifei
;
Cheng, Kai
;
Li, Jiaomeng
;
Sun, Xiaochu
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
Sulfhydryl-containing metabolites
Stable isotope labeling
Identification
Quantification
Hyperlipidemia
Oxidative stress
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Fast determination of 16 circulating neurotransmitters and their metabolites in plasma samples of spontaneously hypertensive rats intervened with five different Uncaria
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1179, 页码: 9
作者:
Gao, Lei
;
Zhang, Zijia
;
Feng, Zijin
;
Wei, Wenlong
;
Wu, Wenyong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
Neurotransmitters
LC-MS
Hypertension
Uncaria
Spontaneously hypertensive rats
Simultaneous determination of sutetinib and its active metabolite sutetinibN-oxide in human plasma by liquid chromatography-tandem mass spectrometry: Evaluation of plasma stability
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2020, 页码: 9
作者:
Qiu, Yanan
;
Tang, Chongzhuang
;
Li, Ranran
;
Cao, Sumin
;
Zhang, Yuqiang
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/24
LC-MS
MS
N-oxide
stability
sutetinib
LysargiNase and Chemical Derivatization Based Strategy for Facilitating In-Depth Profiling of C-Terminome
期刊论文
ANALYTICAL CHEMISTRY, 2019, 卷号: 91, 期号: 22, 页码: 14522-14529
作者:
Hu, Hao
;
Zhao, Wensi
;
Zhu, Mengdi
;
Zhao, Lei
;
Zhai, Linhui
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
pretreatmentwithbroadspectrumantibioticsaltersthepharmacokineticsofmajorconstituentsofshaoyaogancaodecoctioninratsafteroraladministration
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 002, 页码: 288
作者:
Meng Liu
;
Jie Yuan
;
Wenjuan Hu
;
Changqiang Ke
;
Yifan Zhang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Shaoyao-Gancao
decoction
broad-spectrum
antibiotics
pharmacokinetics
drug-drug
interaction
intestinal
microbiota
Development and validation of a highly sensitive LC-MS/MS method for determination of brain active agent dianhydrogalactitol in mouse plasma and tissues: Application to a pharmacokinetic study
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2018, 卷号: 1087, 页码: 90-97
作者:
Sun, Lihan
;
Wu, Huajing
;
Ren, Lianjie
;
Cong, Jiaojiao
;
Qin, Xiaohui
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
1,2:5,6-dianhydrogalactitol
Derivatization
LC-MS/MS
Plasma
Tissue distribution
Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Liu, Meng
;
Yuan, Jie
;
Hu, Wen-Juan
;
Ke, Chang-Qiang
;
Zhang, Yi-Fan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 149, 页码: 394-402
作者:
Liu, Cai
;
Lu, Youming
;
Sun, Hongbin
;
Yang, Jin
;
Liu, Yongqiang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
Active metabolite
LC-MS/MS
Human plasma
P2Y(12) inhibitor
Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 24, 页码: 11050-11068
作者:
Liu, Gang
;
Xue, Ding
;
Yang, Jun
;
Wan, Juan
;
Liu, Xiaohua
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
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