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科研机构
上海药物研究所 [58]
内容类型
期刊论文 [54]
会议论文 [4]
发表日期
2021 [7]
2020 [3]
2019 [4]
2018 [6]
2017 [6]
2016 [6]
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Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 10, 页码: 2260-2269
作者:
Yin, Jianpeng
;
Zhan, Desheng
;
Ma, Hui
;
Liu, Huanan
;
Yu, Lifang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/12/16
YLF466D
AMPK activator
glucose metabolism
lipid metabolism
MIRI
domino reaction
C-H activation
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal T-reg cells
期刊论文
NATURE NEUROSCIENCE, 2021, 页码: 33
作者:
Xu, Zhipeng
;
Zhang, Xiaoyun
;
Chang, Hao
;
Kong, Yue
;
Ni, Yangyue
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/05/24
Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus
期刊论文
NEUROSCIENCE LETTERS, 2021, 卷号: 744, 页码: 7
作者:
Abame, Melkamu Alemu
;
He, Yang
;
Wu, Song
;
Xie, Zhifei
;
Zhang, Jian
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
Synthetic cannabidiol
Depression
Serotonin
Noradrenaline
Nuclear factor kappa B
TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 卷号: 11, 期号: 4, 页码: 1632-1645
作者:
Wang, Lei
;
Zhu, Xi
;
Li, Lili
;
Li, Lin
;
Fu, Li
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2021/06/11
PARP
DNA damage
hematologic toxicity
beta-glucuronidase
tumor selectivity
Original Pharmacodynamic and pharmacokinetic effects of S086, a novel angiotensin receptor neprilysin inhibitor
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2020, 卷号: 129, 页码: 10
作者:
Sun, Jingchao
;
Xu, Wenjie
;
Hua, Huaijie
;
Xiao, Ying
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
Angiotensin receptor-NEP inhibitor
Heart failure
Neprilysin inhibitor
Angiotensin receptor blocker
Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 3956-3975
作者:
Li, Zizhou
;
Xiao, Senhao
;
Yang, Yaxi
;
Chen, Chao
;
Lu, Tian
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain derived neurotrophic factor (BDNF) expression level in the hippocampus
期刊论文
NEUROBIOLOGY OF LEARNING AND MEMORY, 2020, 卷号: 167, 页码: 10
作者:
Wu, Chunhui
;
Wang, Yu
;
He, Yang
;
Wu, Song
;
Xie, Zhifei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Ketamine
Sub-anesthetic dose
Anesthetic dose
Depression
Cognition
Anxiety
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