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科研机构
上海药物研究所 [29]
内容类型
期刊论文 [25]
项目 [4]
发表日期
2021 [3]
2020 [7]
2019 [4]
2018 [5]
2017 [5]
2016 [1]
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Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
Anti-nociceptive, anti-inflammatory and anti-arthritic activities of pregnane glycosides from the root bark of Periploca sepium Bunge
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 265, 页码: 12
作者:
Lin, Ze-min
;
Liu, Yu-ting
;
Huang, Yue-teng
;
Yang, Xiao-qian
;
Zhu, Feng-hua
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
Periploca sepium Bunge
Pregnane glycosides
Anti-nociceptive activity
Anti-inflammatory activity
Anti-arthritic activity
Inflammatory arthritis
Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer
期刊论文
CANCER MEDICINE, 2020, 页码: 12
作者:
Pan, Deng
;
Tang, Yubo
;
Tong, Jiao
;
Xie, Chengmei
;
Chen, Jiaxi
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/24
Collaborative Personalized Cancer Medicine Team Grant from the Princess Margaret Cancer Centre
项目
资助机构: Collaborative Personalized Cancer Medicine Team Grant from the Princess Margaret Cancer Centre, 2020-
-
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/12/24
Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies
期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 12
作者:
Xuan, Yue
;
Bateman, Nicholas W.
;
Gallien, Sebastien
;
Goetze, Sandra
;
Zhou, Yue
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
Molecular dynamics simulations reveal the mechanism of the interactions between the inhibitors and SIRT2 at atom level
期刊论文
MOLECULAR SIMULATION, 2020, 卷号: 46, 期号: 8, 页码: 638-649
作者:
Wang, Xiaoyu
;
Song, Menghua
;
Zhao, Shuang
;
Li, Huiyu
;
Zhao, Qingjie
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
SIRT2
inhibitor
molecular dynamics simulation
TCMs
hydrophobic and pi-pi interactions
TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 7, 页码: 3665-3677
作者:
Qiu, Yunguang
;
Huang, Lu
;
Fu, Jie
;
Han, Chenxia
;
Fang, Jing
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Xie, Zhu-qing
;
Tian, Xiao-ting
;
Zheng, Yue-ming
;
Zhan, Li
;
Chen, Xue-qin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
geissoschizine methyl ether
Uncaria rhynchophyll
antiepileptic drug
hippocampal neurons
action potential
nicotinic acetylcholine receptors
voltage-gated ion channels
mouse seizure model
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