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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [12]
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2021 [1]
2020 [1]
2017 [2]
2016 [1]
2015 [3]
2014 [2]
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Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 252, 页码: 9
作者:
Cong, Jiaojiao
;
Ruan, Yiling
;
Lyu, Qinglin
;
Qin, Xiaohui
;
Qi, Xinming
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Aconitum alkaloids
Blood-brain barrier
Proton-coupled organic cation antiporter
hCMEC/D3 cells
Drug transport
Puquitinib, a novel orally available PI3K inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia
期刊论文
CANCER SCIENCE, 2017, 卷号: 108, 期号: 7, 页码: 1476-1484
作者:
Xie, Chengying
;
He, Ye
;
Zhen, Mingyue
;
Wang, Yulan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Acute myeloid leukemia
CAL-101
PI3K signaling
PI3K
puquitinib
W2476 ameliorates beta-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1024-1037
作者:
Li, Ting
;
Lin, Guang-yao
;
Zhong, Li
;
Zhou, Yan
;
Wang, Jia
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
diabetes
glucose
TXNIP
beta-cells
W2476
high-throughput screening
Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 103, 页码: 118-128
作者:
Liu, Xia
;
Xu, Zhijian
;
Hou, Chuanwei
;
Wang, Meng
;
Chen, Xinhuan
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Hepatitis B virus
Viral genomic DNA and cccDNA synthesis
Human ribonucleotide reductase small subunit M2 (RRM2)
Small molecule compounds
Drug synergism and drug resistance
A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 卷号: 59, 期号: 11, 页码: 7061-7072
作者:
Wang, Ya-Juan
;
Lu, Dong
;
Xu, Yi-Bin
;
Xing, Wei-Qiang
;
Tong, Xian-Kun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2015, 卷号: 9, 页码: 4861-4868
作者:
Gao, Hong
;
Ruan, Jianqing Q.
;
Chen, Jie
;
Li, Na
;
Ke, Changqiang Q.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
drug-induced liver injury
herb
blood protein adducts
prognostic marker
The role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity
期刊论文
TOXICOLOGY RESEARCH, 2015, 卷号: 4, 期号: 5, 页码: 1260-1268
作者:
Li, Chunzhu
;
Xing, Guozhen
;
Maeda, Kazuya
;
Wu, Chunyong
;
Gong, Likun
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation
期刊论文
International immunopharmacology, 2014, 卷号: 23, 期号: 1, 页码: 170-8
作者:
Dou, Wei
;
Zhang, Jingjing
;
Ren, Gaiyan
;
Ding, Lili
;
Sun, Aning
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica
期刊论文
Journal of separation science, 2014, 卷号: 37, 期号: 15, 页码: 2032-8
作者:
Fang, Lianxiang
;
Xiong, Aizhen
;
Yang, Xiao
;
Cheng, Wenzhi
;
Yang, Li
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
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