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科研机构
上海药物研究所 [81]
内容类型
期刊论文 [81]
发表日期
2021 [3]
2020 [7]
2019 [2]
2018 [7]
2017 [3]
2016 [7]
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Environmen... [1]
Pharmacolo... [1]
Toxicology [1]
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SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade
期刊论文
EMBO JOURNAL, 2021, 页码: 16
作者:
Wang, Xu
;
Ni, Jiahui
;
You, Yan
;
Feng, Guize
;
Zhang, Sulin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/12/16
E-cadherin
IBD
intestinal barrier function
LPS release
SNX10
Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains
期刊论文
IMMUNITY, 2021, 卷号: 54, 期号: 10, 页码: 2218-+
作者:
Song, Bin
;
Chen, Yun
;
Liu, Xin
;
Yuan, Fei
;
Tan, Eddie Yong Jun
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/12/01
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 卷号: 120, 页码: 12
作者:
Huang, Suling
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2021/08/17
Macrophage
NLRP3 inflammasome
Hepatic lipid accumulation
NASH
FXR
Short-term exposure to ZnO/MCB persistent free radical particles causes mouse lung lesions via inflammatory reactions and apoptosis pathways
期刊论文
ENVIRONMENTAL POLLUTION, 2020, 卷号: 261, 页码: 8
作者:
Zhang, Xing
;
Gu, Wenyi
;
Ma, Zhongliang
;
Liu, Yun
;
Ru, Hongbo
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Environmentally persistent free radicals
Lung cells and tissues
Oxidative stress
Inflammatory
Apoptosis
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2020, 卷号: 18, 期号: 5, 页码: 345-355
作者:
Li Xue-Ying
;
Tao Hong
;
Jin Can
;
Du Zhen-Yun
;
Liao Wen-Feng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Cordycepin
FGFR2
Apoptosis
Pancreatic cancer
Ras/Erk
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 卷号: 35, 期号: 1, 页码: 1674-1684
作者:
Firoozpour, Loghman
;
Gao, Lixin
;
Moghimi, Setareh
;
Pasalar, Parvin
;
Davoodi, Jamshid
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
Caspase inhibitor
Isatin sulphonamides
docking studies
Pharmacophore
apoptosis
discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415
作者:
Lai Mengzhen
;
Song Peiran
;
Dou Dou
;
Diao Yanyan
;
Tong Linjiang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton’s tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
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