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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [12]
发表日期
2020 [1]
2017 [1]
2016 [1]
2014 [2]
2013 [1]
2012 [3]
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Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 198, 页码: 11
作者:
Wang, Zhi-Cheng
;
Wei, Bingyan
;
Pei, Fang-Ning
;
Yang, Teng
;
Tang, Jie
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/12/24
Capsaicin
Nitrothiophene
Multidrug-resistant S. aureus
Antibacterial agent
Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270
作者:
Zhang, Wei-yao
;
Lu, Wen-chao
;
Jiang, Hao
;
Lv, Zheng-bing
;
Xie, Yi-qian
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
epigenetics
molecular docking
PRMT1
scaffold hopping
small-molecule inhibitor
Synthesis of Key Impurities as Quality Control Standards of Oxfendazole
期刊论文
Chinese Journal of Applied Chemistry, 2016, 卷号: 33, 期号: 9, 页码: 1061-1066
作者:
Li Zhao
;
Feng Jia
;
Gao Yuanyuan
;
Li Bo
;
Zhu Weiliang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
oxfendazole
impurity
standard substances
synthesis
Enantioselective HPLC determination and pharmacokinetic study of secnidazole enantiomers in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2014, 卷号: 965, 页码: 224-230
作者:
Du, Jiangbo
;
Zhang, Yifan
;
Chen, Yao
;
Liu, Dongqin
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Secnidazole
Enantiomers
Enantioselective high-performance liquid chromatography
Pharmacokinetics
Simultaneous determination of ornidazole and its main metabolites in human plasma by LC-MS/MS: application to a pharmacokinetic study
期刊论文
BIOANALYSIS, 2014, 卷号: 6, 期号: 18, 页码: 2343-2356
作者:
Du, Jiangbo
;
Ma, Zhiyu
;
Zhang, Yifan
;
Wang, Ting
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Stereoselective Glucuronidation of Ornidazole in Humans: Predominant Contribution of UDP-Glucuronosyltransferases 1A9 and 2B7
期刊论文
DRUG METABOLISM AND DISPOSITION, 2013, 卷号: 41, 期号: 7, 页码: 1306-1318
作者:
Du, Jiangbo
;
You, Tiangeng
;
Chen, Xiaoyan
;
Zhong, Dafang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G(2)-M arrest and apoptosis in HeLa cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 3, 页码: 407-417
作者:
Ma, Yi-ming
;
Zhou, Yu-bo
;
Xie, Chuan-ming
;
Chen, Dong-mei
;
Li, Jia
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
anticancer drug
6-chloro-4-(methoxyphenyl) coumarin
cell cycle arrest
microtubule depolymerization
apoptosis
Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
期刊论文
DRUG METABOLISM AND DISPOSITION, 2012, 卷号: 40, 期号: 3, 页码: 556-567
作者:
Gao, Ruina
;
Li, Liang
;
Xie, Cen
;
Diao, Xingxing
;
Zhong, Dafang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G_2-M arrest and apoptosis in HeLa cells
期刊论文
Acta Pharmacologica Sinica, 2012, 卷号: 33, 期号: 3, 页码: 407
作者:
Ma Yiming
;
Zhou Yubo
;
Xie Chuanming
;
Chen Dongmei
;
Li Jia
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
ACTIVATED PROTEIN-KINASE
TUBULIN-BINDING AGENT
IN-VIVO
ANTIMICROBIAL ACTIVITY
ANTICANCER ACTIVITY
CYCLE ARREST
CANCER-CELLS
DERIVATIVES
INHIBITOR
RESISTANT
anticancer drug
6-chloro-4-(methoxyphenyl) coumarin
cell cycle arrest
microtubule depolymerization
apoptosis
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori
期刊论文
FEBS JOURNAL, 2006, 卷号: 273, 期号: 20, 页码: 4682-4692
作者:
Han, Cong
;
Wang, Lirui
;
Yu, Kunqian
;
Chen, Lili
;
Hu, Lihong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
antibacterial agent
drug target
enzyme inhibition
Helicobacter pylori
shikimate dehydrogenase
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